{"id":89176,"date":"2026-09-18T15:59:25","date_gmt":"2026-09-18T11:59:25","guid":{"rendered":"https:\/\/sheniekimi.ge\/ambebi\/?p=89176"},"modified":"2026-09-25T20:43:39","modified_gmt":"2026-09-25T16:43:39","slug":"%e1%83%9d%e1%83%a0%e1%83%98-%e1%83%aa%e1%83%98%e1%83%9a%e1%83%90-%e1%83%a8%e1%83%94%e1%83%a1%e1%83%90%e1%83%ab%e1%83%9a%e1%83%9d%e1%83%90-%e1%83%9e%e1%83%90%e1%83%a0%e1%83%99%e1%83%98%e1%83%9c","status":"publish","type":"post","link":"https:\/\/sheniekimi.ge\/ambebi\/%e1%83%9d%e1%83%a0%e1%83%98-%e1%83%aa%e1%83%98%e1%83%9a%e1%83%90-%e1%83%a8%e1%83%94%e1%83%a1%e1%83%90%e1%83%ab%e1%83%9a%e1%83%9d%e1%83%90-%e1%83%9e%e1%83%90%e1%83%a0%e1%83%99%e1%83%98%e1%83%9c\/","title":{"rendered":"\u10dd\u10e0\u10d8 \u10ea\u10d8\u10da\u10d0 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d7\u10d0\u10d5\u10d8\u10e1 \u10e2\u10d5\u10d8\u10dc\u10e8\u10d8 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10d3\u10d4\u10e1 \u10ee\u10d4\u10da\u10e1 \u2014 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10d0\u10ee\u10d0\u10da \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4\u10e1 \u10d0\u10d5\u10da\u10d4\u10dc\u10e1"},"content":{"rendered":"<h1>\u10dd\u10e0\u10d8 \u10ea\u10d8\u10da\u10d0 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0\u10e8\u10d8 \u10db\u10dd\u10dc\u10d0\u10ec\u10d8\u10da\u10d4\u10dd\u10d1\u10d3\u10d4\u10e1 \u2014 \u10d0\u10ee\u10d0\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4\u10e1 \u10d0\u10d5\u10da\u10d4\u10dc\u10e1<\/h1>\n<h2>\u10e8\u10d4\u10e1\u10d0\u10d5\u10d0\u10da\u10d8 \u2014 \u10d0\u10dc\u10d0\u10da\u10d8\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10dd\u10db\u10d4\u10dc\u10e2\u10d0\u10e0\u10d8<\/h2>\n<p><strong>\u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7\u10d8 \u10e7\u10d5\u10d4\u10da\u10d0\u10d6\u10d4 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d0 \u10d3\u10e6\u10d4\u10e1 \u10d0\u10e0\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10e3\u10d9\u10d5\u10d4 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8, \u10d0\u10e0\u10d0\u10db\u10d4\u10d3 \u10d8\u10db \u10d1\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d4\u10d1\u10d8\u10e1 <a href=\"https:\/\/sheniekimi.ge\/\" target=\"_blank\" rel=\"noopener\">\u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d0\u10d0<\/a><\/strong>, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10dc\u10d4\u10e0\u10d5\u10e3\u10da\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10e4\u10e3\u10eb\u10d5\u10d4\u10da\u10e1 \u10e5\u10db\u10dc\u10d8\u10e1. \u10e1\u10ec\u10dd\u10e0\u10d4\u10d3 \u10d0\u10db \u10d9\u10dd\u10dc\u10e2\u10d4\u10e5\u10e1\u10e2\u10e8\u10d8 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10e3\u10da \u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10e1 \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10e4\u10dd\u10e0\u10db\u10d4\u10d1\u10d8\u10e1 \u10d4\u10e0\u10d7\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10d3\u10d0\u10dc \u10db\u10d4\u10dd\u10e0\u10d4\u10e8\u10d8 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d0.<\/p>\n<p>2024 \u10ec\u10d4\u10da\u10e1 \u10df\u10e3\u10e0\u10dc\u10d0\u10da\u10e8\u10d8 <em>Nature Communications<\/em> \u10d2\u10d0\u10db\u10dd\u10e5\u10d5\u10d4\u10e7\u10dc\u10d4\u10d1\u10e3\u10da\u10db\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d0\u10e6\u10ec\u10d4\u10e0\u10d0 \u10dd\u10e0\u10d8 \u10ea\u10d8\u10da\u10d8\u10e1 \u2014 Aplp1-\u10d8\u10e1\u10d0 \u10d3\u10d0 Lag3-\u10d8\u10e1 \u2014 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10e8\u10d8 \u10e8\u10d4\u10e6\u10ec\u10d4\u10d5\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d2\u10dd\u10db \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1 \u10ee\u10d4\u10da\u10e1. \u10db\u10d9\u10d5\u10da\u10d4\u10d5\u10e0\u10d4\u10d1\u10db\u10d0 \u10d7\u10d0\u10d2\u10d5\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10e8\u10d8 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10e1, \u10e0\u10dd\u10db \u10dd\u10e0\u10d8\u10d5\u10d4 \u10ea\u10d8\u10da\u10d8\u10e1 \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d8 \u10db\u10dd\u10ea\u10d8\u10da\u10d4\u10d1\u10d0 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10dc\u10d0\u10d3 \u10d0\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d3\u10d0 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10ea\u10d8\u10da\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10ea\u10d4\u10db\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da \u10ea\u10d5\u10da\u10d8\u10da\u10d4\u10d1\u10d4\u10d1\u10e1. \u10d0\u10dc\u10e2\u10d8-Lag3 \u10d0\u10dc\u10e2\u10d8\u10e1\u10ee\u10d4\u10e3\u10da\u10db\u10d0\u10ea \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d8 \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d8\u10d7 \u10d8\u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d0 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p>\u10d0\u10db \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d0 \u10d8\u10db\u10d8\u10d7\u10d0\u10ea \u10d8\u10d6\u10e0\u10d3\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db Lag3 \u10e3\u10d9\u10d5\u10d4 \u10d0\u10e0\u10d8\u10e1 \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4 \u10d9\u10d8\u10d1\u10dd\u10e1 \u10d8\u10db\u10e3\u10dc\u10dd\u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0\u10e8\u10d8. \u10d7\u10e3\u10db\u10ea\u10d0 \u10d0\u10e5 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10db\u10d9\u10d0\u10e4\u10d8\u10dd \u10d2\u10d0\u10dc\u10e1\u10ee\u10d5\u10d0\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d9\u10d4\u10d7\u10d4\u10d1\u10d0: \u10d9\u10d8\u10d1\u10dd\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8 Lag3-\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d0 <strong>\u10d0\u10e0 \u10dc\u10d8\u10e8\u10dc\u10d0\u10d5\u10e1<\/strong>, \u10e0\u10dd\u10db \u10d8\u10d2\u10d8 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8\u10d0. \u10d0\u10e8\u10e8-\u10d8\u10e1 \u10e1\u10e3\u10e0\u10e1\u10d0\u10d7\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d0\u10d3\u10db\u10d8\u10dc\u10d8\u10e1\u10e2\u10e0\u10d0\u10ea\u10d8\u10d8\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8\u10d7, \u10dc\u10d8\u10d5\u10dd\u10da\u10e3\u10db\u10d0\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e0\u10d4\u10da\u10d0\u10e2\u10da\u10d8\u10db\u10d0\u10d1\u10d8\u10e1 \u10d9\u10dd\u10db\u10d1\u10d8\u10dc\u10d0\u10ea\u10d8\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d8 \u10db\u10d4\u10da\u10d0\u10dc\u10dd\u10db\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3. (<a title=\"Search Orphan Drug Designations and Approvals\" href=\"https:\/\/www.accessdata.fda.gov\/scripts\/opdlisting\/oopd\/detailedIndex.cfm?cfgridkey=595017&amp;utm_source=chatgpt.com\">FDA Access Data<\/a>)<\/p>\n<p>\u10d0\u10db\u10e0\u10d8\u10d2\u10d0\u10d3, \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10ec\u10d0\u10e0\u10db\u10dd\u10d0\u10d3\u10d2\u10d4\u10dc\u10e1 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd \u10d0\u10ee\u10d0\u10da\u10d8 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d0\u10e1 \u10d3\u10d0 \u10d0\u10e0\u10d0 \u10e3\u10d9\u10d5\u10d4 \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0\u10e1.<\/p>\n<h2>\u10de\u10e0\u10dd\u10d1\u10da\u10d4\u10db\u10d8\u10e1 \u10d0\u10e6\u10ec\u10d4\u10e0\u10d0<\/h2>\n<p>\u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10d0\u10d3\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d0\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10de\u10d8\u10e0\u10d5\u10d4\u10da \u10e0\u10d8\u10d2\u10e8\u10d8 \u10db\u10dd\u10eb\u10e0\u10d0\u10dd\u10d1\u10d8\u10e1 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da \u10dc\u10d4\u10e0\u10d5\u10e3\u10da \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d0\u10e1 \u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10e1. \u10d3\u10d0\u10db\u10d0\u10ee\u10d0\u10e1\u10d8\u10d0\u10d7\u10d4\u10d1\u10d4\u10da \u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1\u10d0\u10d0 \u10db\u10dd\u10eb\u10e0\u10d0\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10dc\u10d4\u10da\u10d4\u10d1\u10d0, \u10d9\u10e3\u10dc\u10d7\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10e8\u10d4\u10e8\u10d4\u10d1\u10d0, \u10db\u10dd\u10e1\u10d5\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10d9\u10d0\u10dc\u10d9\u10d0\u10da\u10d8 \u10d3\u10d0 \u10ec\u10dd\u10dc\u10d0\u10e1\u10ec\u10dd\u10e0\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d0. \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10e1 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d0\u10ee\u10da\u10d3\u10d4\u10e1 \u10eb\u10d8\u10da\u10d8\u10e1, \u10e7\u10dc\u10dd\u10e1\u10d5\u10d8\u10e1, \u10d9\u10dd\u10d2\u10dc\u10d8\u10e2\u10d8\u10e3\u10e0\u10d8 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d4\u10d1\u10d8\u10e1, \u10d2\u10d0\u10dc\u10ec\u10e7\u10dd\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10d0\u10e0\u10d0\u10db\u10dd\u10e2\u10dd\u10e0\u10e3\u10da\u10d8 \u10de\u10e0\u10dd\u10d1\u10da\u10d4\u10db\u10d4\u10d1\u10d8\u10ea. (<a title=\"Parkinson disease\" href=\"https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/parkinson-disease?utm_source=chatgpt.com\">World Health Organization<\/a>)<\/p>\n<p>\u10db\u10e1\u10dd\u10e4\u10da\u10d8\u10dd \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10dd\u10e0\u10d2\u10d0\u10dc\u10d8\u10d6\u10d0\u10ea\u10d8\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d8\u10d7, 2019 \u10ec\u10d4\u10da\u10e1 \u10db\u10e1\u10dd\u10e4\u10da\u10d8\u10dd\u10e8\u10d8 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10d7 8,5 \u10db\u10d8\u10da\u10d8\u10dd\u10dc\u10d6\u10d4 \u10db\u10d4\u10e2\u10d8 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8 \u10ea\u10ee\u10dd\u10d5\u10e0\u10dd\u10d1\u10d3\u10d0. \u10d1\u10dd\u10da\u10dd 25 \u10ec\u10da\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0 \u10d3\u10d0\u10d0\u10ee\u10da\u10dd\u10d4\u10d1\u10d8\u10d7 \u10d2\u10d0\u10dd\u10e0\u10db\u10d0\u10d2\u10d3\u10d0. \u10d8\u10db\u10d0\u10d5\u10d4 \u10ec\u10da\u10d8\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8\u10d7, \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10db \u10d3\u10d0\u10d0\u10ee\u10da\u10dd\u10d4\u10d1\u10d8\u10d7 5,8 \u10db\u10d8\u10da\u10d8\u10dd\u10dc\u10d8 \u10d8\u10dc\u10d5\u10d0\u10da\u10d8\u10d3\u10dd\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e1\u10d8\u10ea\u10dd\u10ea\u10ee\u10da\u10d8\u10e1 \u10ec\u10da\u10d8\u10d7\u10d0 \u10d3\u10d0 329 \u10d0\u10d7\u10d0\u10e1\u10d8 \u10e1\u10d8\u10d9\u10d5\u10d3\u10d8\u10da\u10d8\u10d7 \u10d2\u10d0\u10dc\u10de\u10d8\u10e0\u10dd\u10d1\u10d4\u10d1\u10e3\u10da\u10d8 \u10e2\u10d5\u10d8\u10e0\u10d7\u10d8 \u10e8\u10d4\u10e5\u10db\u10dc\u10d0. (<a title=\"Launch of WHO's Parkinson disease technical brief\" href=\"https:\/\/www.who.int\/news\/item\/14-06-2022-launch-of-who-s-parkinson-disease-technical-brief?utm_source=chatgpt.com\">World Health Organization<\/a>)<\/p>\n<p>\u10d4\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10e1\u10d0\u10e5\u10d0\u10e0\u10d7\u10d5\u10d4\u10da\u10dd\u10e1\u10d7\u10d5\u10d8\u10e1\u10d0\u10ea, \u10e0\u10d0\u10d3\u10d2\u10d0\u10dc \u10db\u10dd\u10e1\u10d0\u10ee\u10da\u10d4\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d1\u10d4\u10e0\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d8\u10d0\u10d2\u10dc\u10dd\u10e1\u10e2\u10d8\u10d9\u10d0, \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d8 \u10db\u10d0\u10e0\u10d7\u10d5\u10d0, \u10e0\u10d4\u10d0\u10d1\u10d8\u10da\u10d8\u10e2\u10d0\u10ea\u10d8\u10d0 \u10d3\u10d0 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10d4\u10d1\u10d6\u10d4 \u10ee\u10d4\u10da\u10db\u10d8\u10e1\u10d0\u10ec\u10d5\u10d3\u10dd\u10db\u10dd\u10d1\u10d0 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10e1\u10e3\u10da \u10e3\u10e4\u10e0\u10dd \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10ee\u10d3\u10d4\u10d1\u10d0.<\/p>\n<p>\u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d7\u10d0\u10dc\u10d0\u10db\u10d4\u10d3\u10e0\u10dd\u10d5\u10d4 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3\u10d0\u10d3 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0\u10d6\u10d4\u10d0 \u10dd\u10e0\u10d8\u10d4\u10dc\u10e2\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8. \u10da\u10d4\u10d5\u10dd\u10d3\u10dd\u10de\u10d0 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8, \u10e4\u10d8\u10d6\u10d8\u10d9\u10e3\u10e0\u10d8 \u10e0\u10d4\u10d0\u10d1\u10d8\u10da\u10d8\u10e2\u10d0\u10ea\u10d8\u10d0, \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10e5\u10d8\u10e0\u10e3\u10e0\u10d2\u10d8\u10e3\u10da\u10d8 \u10db\u10d8\u10d3\u10d2\u10dd\u10db\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10d3\u10d0\u10db\u10ee\u10db\u10d0\u10e0\u10d4 \u10db\u10d4\u10d7\u10dd\u10d3\u10d4\u10d1\u10d8 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10e3\u10e0 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10ea\u10ee\u10dd\u10d5\u10e0\u10d4\u10d1\u10d8\u10e1 \u10ee\u10d0\u10e0\u10d8\u10e1\u10ee\u10e1 \u10d0\u10e3\u10db\u10ef\u10dd\u10d1\u10d4\u10e1\u10d4\u10d1\u10e1, \u10d7\u10e3\u10db\u10ea\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10db\u10ec\u10d5\u10d4\u10d5\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d8\u10e1 \u10e8\u10d4\u10e9\u10d4\u10e0\u10d4\u10d1\u10d0 \u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10d7 \u10e8\u10d4\u10e3\u10eb\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0. (<a title=\"Parkinson disease\" href=\"https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/parkinson-disease?utm_source=chatgpt.com\">World Health Organization<\/a>)<\/p>\n<p>\u10d0\u10db\u10d8\u10e2\u10dd\u10db \u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10d8\u10e1\u10d4\u10d7\u10d8 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d7\u10d0 \u10d6\u10d4\u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d8\u10d7\u10d0\u10ea \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10d0\u10d6\u10d4 \u10d2\u10d0\u10d5\u10da\u10d4\u10dc\u10d8\u10e1 \u10db\u10dd\u10ee\u10d3\u10d4\u10dc\u10d0.<\/p>\n<h2>\u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10d3\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d0\u10da\u10d8\u10d6\u10d8<\/h2>\n<p>\u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7\u10d8 \u10ea\u10d4\u10dc\u10e2\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10d1\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d7\u10d0\u10d5\u10d8\u10e1\u10d4\u10d1\u10e3\u10e0\u10d4\u10d1\u10d0\u10d0 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10d0\u10e0\u10d0\u10e1\u10ec\u10dd\u10e0\u10d0\u10d3 \u10d3\u10d0\u10d9\u10d4\u10ea\u10d8\u10da\u10d8 \u10d3\u10d0 \u10d0\u10d2\u10e0\u10d4\u10d2\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e4\u10dd\u10e0\u10db\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d2\u10e0\u10dd\u10d5\u10d4\u10d1\u10d0. \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8 \u10e9\u10d5\u10d4\u10e3\u10da\u10d4\u10d1\u10e0\u10d8\u10d5 \u10dc\u10d4\u10e0\u10d5\u10e3\u10da \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e8\u10d8 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10ea\u10d8\u10da\u10d0\u10d0, \u10d7\u10e3\u10db\u10ea\u10d0 \u10db\u10d8\u10e1\u10d8 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10e4\u10dd\u10e0\u10db\u10d4\u10d1\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d4\u10e0\u10d7\u10db\u10d0\u10dc\u10d4\u10d7\u10d7\u10d0\u10dc \u10d2\u10d0\u10d4\u10e0\u10d7\u10d8\u10d0\u10dc\u10d3\u10d4\u10e1 \u10d3\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10e1\u10d0\u10d6\u10d8\u10d0\u10dc\u10dd \u10e1\u10e2\u10e0\u10e3\u10e5\u10e2\u10e3\u10e0\u10d4\u10d1\u10d8 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0\u10e1.<\/p>\n<p>\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d8 \u10e1\u10e3\u10da \u10e3\u10e4\u10e0\u10dd \u10db\u10d4\u10e2 \u10e7\u10e3\u10e0\u10d0\u10d3\u10e6\u10d4\u10d1\u10d0\u10e1 \u10d0\u10e5\u10ea\u10d4\u10d5\u10d4\u10dc \u10f0\u10d8\u10de\u10dd\u10d7\u10d4\u10d6\u10d0\u10e1, \u10e0\u10dd\u10db\u10da\u10d8\u10e1 \u10db\u10d8\u10ee\u10d4\u10d3\u10d5\u10d8\u10d7\u10d0\u10ea \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d4\u10e0\u10d7\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10d3\u10d0\u10dc \u10db\u10d4\u10dd\u10e0\u10d4\u10e8\u10d8 \u10d2\u10d0\u10d3\u10d0\u10d5\u10d8\u10d3\u10d4\u10e1 \u10d3\u10d0 \u10d0\u10db \u10d2\u10d6\u10d8\u10d7 \u10dc\u10d4\u10e0\u10d5\u10e3\u10da \u10e5\u10e1\u10d4\u10da\u10d4\u10d1\u10e8\u10d8 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0\u10e1 \u10e8\u10d4\u10e3\u10ec\u10e7\u10dd\u10e1 \u10ee\u10d4\u10da\u10d8. \u10d4\u10e1 \u10d0\u10e0 \u10dc\u10d8\u10e8\u10dc\u10d0\u10d5\u10e1, \u10e0\u10dd\u10db \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 \u10d8\u10dc\u10e4\u10d4\u10e5\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10d0. \u10e1\u10d0\u10e5\u10db\u10d4 \u10d4\u10ee\u10d4\u10d1\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10ea\u10d8\u10da\u10d8\u10e1 \u10d1\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0 \u10d2\u10d0\u10d3\u10d0\u10ea\u10d4\u10db\u10d0\u10e1 \u10d3\u10d0 \u10d0\u10e0\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10d3\u10d0\u10dc \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d6\u10d4 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10d3\u10d4\u10d1\u10d0\u10e1. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p>\u10e1\u10ec\u10dd\u10e0\u10d4\u10d3 \u10d0\u10db \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10e8\u10d8 \u10e8\u10d4\u10d8\u10e1\u10ec\u10d0\u10d5\u10da\u10d4\u10e1 \u10db\u10d9\u10d5\u10da\u10d4\u10d5\u10e0\u10d4\u10d1\u10db\u10d0 Aplp1 \u10d3\u10d0 Lag3.<\/p>\n<p>Aplp1 \u10db\u10d8\u10d4\u10d9\u10e3\u10d7\u10d5\u10dc\u10d4\u10d1\u10d0 \u10d0\u10db\u10d8\u10da\u10dd\u10d8\u10d3\u10d8\u10e1 \u10ec\u10d8\u10dc\u10d0\u10db\u10dd\u10e0\u10d1\u10d4\u10d3\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10ea\u10d8\u10da\u10d4\u10d1\u10d8\u10e1 \u10dd\u10ef\u10d0\u10ee\u10e1, \u10ee\u10dd\u10da\u10dd Lag3 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10e1 \u10d6\u10d4\u10d3\u10d0\u10de\u10d8\u10e0\u10d6\u10d4 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10dd\u10e0\u10d8\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10d8\u10db\u10e3\u10dc\u10e3\u10e0 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d0\u10e8\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d4\u10d1\u10e1 \u10d0\u10e1\u10e0\u10e3\u10da\u10d4\u10d1\u10e1. \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db \u10d4\u10e1 \u10dd\u10e0\u10d8 \u10ea\u10d8\u10da\u10d0 \u10d4\u10e0\u10d7\u10db\u10d0\u10dc\u10d4\u10d7\u10d7\u10d0\u10dc \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10e1 \u10d3\u10d0 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10e8\u10d8 \u10e8\u10d4\u10e6\u10ec\u10d4\u10d5\u10d0\u10e1 \u10ee\u10d4\u10da\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p>\u10db\u10d9\u10d5\u10da\u10d4\u10d5\u10e0\u10d4\u10d1\u10db\u10d0 \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10db\u10d8\u10d3\u10d2\u10dd\u10db\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10e1. \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10d8\u10e7\u10dd \u10dc\u10d4\u10e0\u10d5\u10e3\u10da\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d9\u10e3\u10da\u10e2\u10e3\u10e0\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10d7\u10d0\u10d2\u10d5\u10d8\u10e1 \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10e8\u10d8\u10ea Aplp1-\u10d8\u10e1\u10d0 \u10d3\u10d0 Lag3-\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d0 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10d4\u10d7\u10dd\u10d3\u10d4\u10d1\u10d8\u10d7 \u10e8\u10d4\u10d8\u10d6\u10e6\u10e3\u10d3\u10d0.<\/p>\n<p>\u10dd\u10e0\u10d8\u10d5\u10d4 \u10ea\u10d8\u10da\u10d8\u10e1 \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d8 \u10db\u10dd\u10ea\u10d8\u10da\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10ea\u10d4\u10db\u10d0 \u10d3\u10d0 \u10db\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10dc\u10d4\u10e0\u10d5\u10e3\u10da\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10d0 \u10db\u10d9\u10d5\u10d4\u10d7\u10e0\u10d0\u10d3 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d3\u10d0. \u10d0\u10d5\u10e2\u10dd\u10e0\u10d4\u10d1\u10db\u10d0 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10e1, \u10e0\u10dd\u10db \u10d0\u10dc\u10e2\u10d8-Lag3 \u10d0\u10dc\u10e2\u10d8\u10e1\u10ee\u10d4\u10e3\u10da\u10e1 \u10e8\u10d4\u10d4\u10eb\u10da\u10dd Aplp1-\u10e1\u10d0 \u10d3\u10d0 Lag3-\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d0 \u10d3\u10d0 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10d8\u10e1 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p>\u10d4\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10e1\u10d0\u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10dd\u10d0, \u10e0\u10d0\u10d3\u10d2\u10d0\u10dc \u10d8\u10d2\u10d8 \u10db\u10d8\u10e3\u10d7\u10d8\u10d7\u10d4\u10d1\u10e1 \u10d0\u10e0\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10d4\u10e0\u10d7 \u10ea\u10d8\u10da\u10d0\u10d6\u10d4, \u10d0\u10e0\u10d0\u10db\u10d4\u10d3 \u10ea\u10d8\u10da\u10d4\u10d1\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0\u10d6\u10d4, \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10e3\u10e0 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4\u10d6\u10d4.<\/p>\n<p>\u10d7\u10e3\u10db\u10ea\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d9\u10e0\u10d8\u10e2\u10d8\u10d9\u10e3\u10da\u10d8 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0. \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10d7\u10d0\u10d2\u10d5\u10d8\u10e1 \u10db\u10dd\u10d3\u10d4\u10da\u10d8 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e1\u10e0\u10e3\u10da\u10d8 \u10d4\u10d9\u10d5\u10d8\u10d5\u10d0\u10da\u10d4\u10dc\u10e2\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1. \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10e8\u10d8 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8, \u10d0\u10e1\u10d0\u10d9\u10dd\u10d1\u10e0\u10d8\u10d5\u10d8, \u10d2\u10d0\u10e0\u10d4\u10db\u10dd\u10e1\u10d0 \u10d3\u10d0 \u10d8\u10db\u10e3\u10dc\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8 \u10d2\u10d0\u10ea\u10d8\u10da\u10d4\u10d1\u10d8\u10d7 \u10e0\u10d7\u10e3\u10da\u10d0\u10d3 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10e1.<\/p>\n<p>\u10d0\u10db\u10d0\u10e1\u10d7\u10d0\u10dc, \u10d7\u10d0\u10d5\u10d0\u10d3 \u10db\u10d9\u10d5\u10da\u10d4\u10d5\u10e0\u10d4\u10d1\u10d8 \u10d0\u10e6\u10dc\u10d8\u10e8\u10dc\u10d0\u10d5\u10d4\u10dc, \u10e0\u10dd\u10db Aplp1-\u10d8\u10e1\u10d0 \u10d3\u10d0 Lag3-\u10d8\u10e1 \u10e4\u10d8\u10d6\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10e0\u10dd\u10da\u10d8 \u10d3\u10d0\u10db\u10d0\u10e2\u10d4\u10d1\u10d8\u10d7 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d0\u10e1 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10e1 \u10d3\u10d0 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10d8\u10db\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d9\u10d5\u10d4\u10d5\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0 \u10db\u10e3\u10e8\u10d0\u10dd\u10d1\u10d4\u10dc \u10d8\u10e1\u10d8\u10dc\u10d8 \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10e2\u10d8\u10de\u10d8\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e8\u10d8. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p>\u10d0\u10db\u10d8\u10e2\u10dd\u10db \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10dc\u10d5\u10d8\u10ee\u10d8\u10da\u10dd\u10d7 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8\u10e1 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d0 \u10d3\u10d0 \u10e1\u10d0\u10db\u10dd\u10db\u10d0\u10d5\u10da\u10dd \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d8\u10e1 \u10d9\u10dd\u10dc\u10ea\u10d4\u10e4\u10ea\u10d8\u10d8\u10e1 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d0, \u10d3\u10d0 \u10d0\u10e0\u10d0 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e3\u10d9\u10d5\u10d4 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0.<\/p>\n<h2>\u10e1\u10e2\u10d0\u10e2\u10d8\u10e1\u10e2\u10d8\u10d9\u10d0 \u10d3\u10d0 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8<\/h2>\n<p>\u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7\u10d8 \u10e7\u10d5\u10d4\u10da\u10d0\u10d6\u10d4 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10d8\u10e7\u10dd \u10d8\u10e1, \u10e0\u10dd\u10db Aplp1-\u10d8\u10e1\u10d0 \u10d3\u10d0 Lag3-\u10d8\u10e1 \u10d4\u10e0\u10d7\u10dd\u10d1\u10da\u10d8\u10d5\u10d8 \u10d3\u10d4\u10e4\u10d8\u10ea\u10d8\u10e2\u10d8 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da \u10de\u10d8\u10e0\u10dd\u10d1\u10d4\u10d1\u10e8\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10dc\u10d0\u10d3 \u10d0\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d3\u10d0 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10e8\u10d4\u10e6\u10ec\u10d4\u10d5\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0\u10e1.<\/p>\n<p>\u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d0\u10d5\u10e2\u10dd\u10e0\u10d4\u10d1\u10db\u10d0 \u10d0\u10e6\u10ec\u10d4\u10e0\u10d4\u10e1, \u10e0\u10dd\u10db \u10dd\u10e0\u10d8\u10d5\u10d4 \u10ea\u10d8\u10da\u10d8\u10e1 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10d4\u10d1\u10e8\u10d8 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10e8\u10d7\u10d0\u10dc\u10d7\u10e5\u10db\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d2\u10d0\u10d3\u10d0\u10ea\u10d4\u10db\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc \u10dc\u10d0\u10ec\u10d8\u10da\u10d7\u10d0\u10dc \u10d8\u10e7\u10dd \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8. \u10db\u10d0\u10d7\u10d8 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10db\u10d8\u10ee\u10d4\u10d3\u10d5\u10d8\u10d7, Aplp1-\u10e1\u10d0 \u10d3\u10d0 Lag3-\u10e1 \u10d4\u10e0\u10d7\u10d0\u10d3 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10ec\u10d5\u10da\u10d8\u10da\u10d8 \u10f0\u10e5\u10dd\u10dc\u10d3\u10d0\u10d7 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10ea\u10d8\u10da\u10d8\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10dc\u10e3\u10da \u10e8\u10d7\u10d0\u10dc\u10d7\u10e5\u10db\u10d0\u10e8\u10d8 \u10d3\u10d0 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0\u10e8\u10d8. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p>\u10d6\u10dd\u10d2\u10d8\u10d4\u10e0\u10d7 \u10db\u10d4\u10d3\u10d8\u10d0\u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d0\u10e8\u10d8 \u10d0\u10db \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10e8\u10d4\u10ef\u10d0\u10db\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10ee\u10d0\u10d6\u10d2\u10d0\u10e1\u10db\u10e3\u10da\u10d8\u10d0 \u10d3\u10d0\u10d0\u10ee\u10da\u10dd\u10d4\u10d1\u10d8\u10d7 90-\u10de\u10e0\u10dd\u10ea\u10d4\u10dc\u10e2\u10d8\u10d0\u10dc\u10d8 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0. \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0, \u10e0\u10dd\u10db \u10d0\u10e1\u10d4\u10d7\u10d8 \u10e0\u10d8\u10ea\u10ee\u10d5\u10d8 \u10d0\u10e0 \u10d8\u10e5\u10dc\u10d4\u10e1 \u10d8\u10dc\u10e2\u10d4\u10e0\u10de\u10e0\u10d4\u10e2\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u201e\u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 90 \u10de\u10e0\u10dd\u10ea\u10d4\u10dc\u10e2\u10d8\u10d7 \u10d2\u10d0\u10dc\u10d9\u10e3\u10e0\u10dc\u10d4\u10d1\u10d0\u201c. \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e8\u10d8 \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10db\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10d4\u10da\u10d8 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10dd\u10d3\u10d0 \u10d3\u10d0 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10d8 \u10d4\u10ee\u10d4\u10d1\u10dd\u10d3\u10d0 \u10d9\u10dd\u10dc\u10d9\u10e0\u10d4\u10e2\u10e3\u10da \u10da\u10d0\u10d1\u10dd\u10e0\u10d0\u10e2\u10dd\u10e0\u10d8\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10e1\u10d0 \u10d3\u10d0 \u10d1\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0 \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d4\u10d1\u10e1.<\/p>\n<p>\u10e3\u10e4\u10e0\u10dd \u10e4\u10d0\u10e0\u10d7\u10dd \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10e1\u10e3\u10e0\u10d0\u10d7\u10d8 \u10d2\u10d0\u10dc\u10e1\u10ee\u10d5\u10d0\u10d5\u10d4\u10d1\u10e3\u10da\u10d8\u10d0. \u10db\u10e1\u10dd\u10e4\u10da\u10d8\u10dd \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10dd\u10e0\u10d2\u10d0\u10dc\u10d8\u10d6\u10d0\u10ea\u10d8\u10d8\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8\u10d7, 2019 \u10ec\u10d4\u10da\u10e1 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10d7 8,5 \u10db\u10d8\u10da\u10d8\u10dd\u10dc\u10d6\u10d4 \u10db\u10d4\u10e2\u10d8 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8 \u10ea\u10ee\u10dd\u10d5\u10e0\u10dd\u10d1\u10d3\u10d0 \u10d3\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10da\u10dd\u10d1\u10d0\u10da\u10e3\u10e0\u10d8 \u10e2\u10d5\u10d8\u10e0\u10d7\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10dc\u10d0\u10d3 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10d0. (<a title=\"Launch of WHO's Parkinson disease technical brief\" href=\"https:\/\/www.who.int\/news\/item\/14-06-2022-launch-of-who-s-parkinson-disease-technical-brief?utm_source=chatgpt.com\">World Health Organization<\/a>)<\/p>\n<p>\u10d3\u10e6\u10d4\u10e1 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10dc\u10d4\u10da\u10d4\u10d1\u10da\u10d0\u10d3 \u10d0\u10dc \u10e8\u10d4\u10e1\u10d0\u10e9\u10d4\u10e0\u10d4\u10d1\u10da\u10d0\u10d3 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10dd\u10d3\u10d8\u10e4\u10d8\u10ea\u10d8\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1. \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10dc\u10d0\u10ec\u10d8\u10da\u10d8 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10e3\u10e0 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d6\u10d4\u10d0 \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d8. (<a title=\"Dopaminergic Therapy for Motor Symptoms in Early Parkinson Disease Practice Guideline Summary: A Report of the AAN Guideline Subcommittee - PMC\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8672433\/?utm_source=chatgpt.com\">PubMed Central (PMC)<\/a>)<\/p>\n<p>\u10e1\u10ec\u10dd\u10e0\u10d4\u10d3 \u10d0\u10db\u10d8\u10e2\u10dd\u10db \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d8\u10e1 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d0\u10d0, \u10d7\u10e3\u10db\u10ea\u10d0 \u10e1\u10d0\u10d1\u10dd\u10da\u10dd\u10dd \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10e1\u10d0\u10e0\u10d2\u10d4\u10d1\u10d4\u10da\u10d0\u10db\u10d3\u10d4 \u10d2\u10d6\u10d0 \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d8\u10db\u10d4 \u10d4\u10e2\u10d0\u10de\u10e1 \u10db\u10dd\u10d8\u10ea\u10d0\u10d5\u10e1: \u10da\u10d0\u10d1\u10dd\u10e0\u10d0\u10e2\u10dd\u10e0\u10d8\u10e3\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0, \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0, \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10de\u10d8\u10e0\u10d5\u10d4\u10da\u10d8 \u10e4\u10d0\u10d6\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 \u10e3\u10e4\u10e0\u10dd \u10e4\u10d0\u10e0\u10d7\u10dd \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10ea\u10d3\u10d4\u10d1\u10d8.<\/p>\n<h2>\u10e1\u10d0\u10d4\u10e0\u10d7\u10d0\u10e8\u10dd\u10e0\u10d8\u10e1\u10dd \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d8\u10da\u10d4\u10d1\u10d0<\/h2>\n<p>\u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d7\u10d0\u10dc\u10d0\u10db\u10d4\u10d3\u10e0\u10dd\u10d5\u10d4 \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7\u10d8 \u10db\u10d7\u10d0\u10d5\u10d0\u10e0\u10d8 \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4\u10d0. \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10ef\u10d2\u10e3\u10e4\u10d8 \u10e1\u10ec\u10d0\u10d5\u10da\u10dd\u10d1\u10e1 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10ea\u10d8\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10e1, \u10d0\u10d2\u10e0\u10d4\u10d2\u10d0\u10ea\u10d8\u10d8\u10e1, \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10ea\u10d4\u10db\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10dd\u10e0\u10d2\u10d0\u10dc\u10d8\u10d6\u10db\u10d8\u10d3\u10d0\u10dc \u10db\u10d8\u10e1\u10d8 \u10db\u10dd\u10ea\u10d8\u10da\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd \u10d2\u10d6\u10d4\u10d1\u10e1. (<a title=\"Targeting Alpha-Synuclein as a Therapy for Parkinson\u2019s Disease - PMC\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC6906193\/?utm_source=chatgpt.com\">PubMed Central (PMC)<\/a>)<\/p>\n<p>Aplp1-Lag3-\u10d8\u10e1 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d0 \u10d0\u10db \u10e4\u10d0\u10e0\u10d7\u10dd \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10d7\u10d8 \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7\u10d8 \u10dc\u10d0\u10ec\u10d8\u10da\u10d8\u10d0. 2024 \u10ec\u10da\u10d8\u10e1 \u10dc\u10d0\u10e8\u10e0\u10dd\u10db\u10d8\u10e1 \u10d0\u10d5\u10e2\u10dd\u10e0\u10d4\u10d1\u10db\u10d0 \u10d3\u10d0\u10d0\u10d3\u10d2\u10d8\u10dc\u10d4\u10e1, \u10e0\u10dd\u10db Lag3-\u10d8\u10e1 \u10d1\u10da\u10dd\u10d9\u10d8\u10e0\u10d4\u10d1\u10d0\u10db \u10d0\u10dc\u10e2\u10d8-Lag3 \u10d0\u10dc\u10e2\u10d8\u10e1\u10ee\u10d4\u10e3\u10da\u10d8\u10d7 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8 \u10e8\u10d4\u10d0\u10e4\u10d4\u10e0\u10ee\u10d0 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10e8\u10d8 \u10e8\u10d4\u10e6\u10ec\u10d4\u10d5\u10d0 \u10d3\u10d0 \u10e8\u10d4\u10d0\u10db\u10ea\u10d8\u10e0\u10d0 \u10db\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10ea\u10d5\u10da\u10d8\u10da\u10d4\u10d1\u10d4\u10d1\u10d8. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p>\u10d0\u10e5 \u10e9\u10dc\u10d3\u10d4\u10d1\u10d0 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10d8\u10e1 \u10e1\u10ee\u10d5\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10d8\u10d3\u10d4\u10d0. \u10d7\u10e3 \u10e3\u10d9\u10d5\u10d4 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10da\u10d8 \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4 \u10d0\u10dc \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8, \u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10e1 \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0\u10d7 \u10e8\u10d4\u10d0\u10e4\u10d0\u10e1\u10dd\u10dc, \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10d7\u10e3 \u10d0\u10e0\u10d0 \u10db\u10d8\u10e1\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1. \u10d0\u10e1\u10d4\u10d7 \u10db\u10d8\u10d3\u10d2\u10dd\u10db\u10d0\u10e1 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10d8\u10e1 \u10d0\u10ee\u10d0\u10da\u10d8 \u10d3\u10d0\u10dc\u10d8\u10e8\u10dc\u10e3\u10da\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0 \u10d4\u10ec\u10dd\u10d3\u10d4\u10d1\u10d0.<\/p>\n<p>Lag3-\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10e3\u10d9\u10d5\u10d4 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10dd\u10dc\u10d9\u10dd\u10da\u10dd\u10d2\u10d8\u10d0\u10e8\u10d8. \u10d0\u10e8\u10e8-\u10d8\u10e1 \u10e1\u10e3\u10e0\u10e1\u10d0\u10d7\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d0\u10d3\u10db\u10d8\u10dc\u10d8\u10e1\u10e2\u10e0\u10d0\u10ea\u10d8\u10d8\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8\u10d7, \u10dc\u10d8\u10d5\u10dd\u10da\u10e3\u10db\u10d0\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e0\u10d4\u10da\u10d0\u10e2\u10da\u10d8\u10db\u10d0\u10d1\u10d8\u10e1 \u10d9\u10dd\u10db\u10d1\u10d8\u10dc\u10d0\u10ea\u10d8\u10d0 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 12 \u10ec\u10da\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e3\u10e4\u10e0\u10dd\u10e1\u10d8 \u10d0\u10e1\u10d0\u10d9\u10d8\u10e1 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d0\u10e0\u10d0\u10dd\u10de\u10d4\u10e0\u10d0\u10d1\u10d4\u10da\u10e3\u10e0\u10d8 \u10d0\u10dc \u10db\u10d4\u10e2\u10d0\u10e1\u10e2\u10d0\u10d6\u10e3\u10e0\u10d8 \u10db\u10d4\u10da\u10d0\u10dc\u10dd\u10db\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d9\u10d5\u10d4\u10e3\u10da \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8. (<a title=\"Search Orphan Drug Designations and Approvals\" href=\"https:\/\/www.accessdata.fda.gov\/scripts\/opdlisting\/oopd\/detailedIndex.cfm?cfgridkey=595017&amp;utm_source=chatgpt.com\">FDA Access Data<\/a>)<\/p>\n<p>\u10d7\u10e3\u10db\u10ea\u10d0 \u10dd\u10dc\u10d9\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d0\u10d5\u10e2\u10dd\u10db\u10d0\u10e2\u10e3\u10e0\u10d0\u10d3 \u10d0\u10e0 \u10dc\u10d8\u10e8\u10dc\u10d0\u10d5\u10e1 \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0\u10e1. \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d8\u10e1 \u10db\u10d0\u10e0\u10d4\u10d2\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d4\u10d1\u10d8\u10e1 \u10ee\u10d4\u10da\u10dd\u10d5\u10dc\u10e3\u10e0\u10d0\u10d3 \u10e8\u10d4\u10ea\u10d5\u10da\u10d0\u10e1 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10db\u10dd\u10f0\u10e7\u10d5\u10d4\u10e1 \u10d0\u10e0\u10d0\u10e1\u10d0\u10e1\u10e3\u10e0\u10d5\u10d4\u10da\u10d8 \u10d8\u10db\u10e3\u10dc\u10e3\u10e0\u10d8 \u10e0\u10d4\u10d0\u10e5\u10ea\u10d8\u10d4\u10d1\u10d8. \u10d0\u10db\u10d8\u10e2\u10dd\u10db \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d0\u10e1\u10d4\u10d7\u10d8 \u10db\u10d8\u10d3\u10d2\u10dd\u10db\u10d8\u10e1 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d0 \u10ea\u10d0\u10da\u10d9\u10d4 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d3\u10d4\u10e1.<\/p>\n<p>2026 \u10ec\u10da\u10d8\u10e1 \u10db\u10d8\u10db\u10dd\u10ee\u10d8\u10da\u10d5\u10d0\u10ea \u10ee\u10d0\u10d6\u10e1 \u10e3\u10e1\u10d5\u10d0\u10db\u10e1, \u10e0\u10dd\u10db \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10e8\u10d8 Lag3-\u10d8\u10e1 \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d4\u10d1\u10d8 \u10ef\u10d4\u10e0 \u10d9\u10d8\u10d3\u10d4\u10d5 \u10ec\u10d8\u10dc\u10d0\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10d4\u10e2\u10d0\u10de\u10d6\u10d4\u10d0 \u10d3\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8\u10d7 \u10db\u10d0\u10d7\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10d0\u10dc\u10dd\u10d1\u10d0 \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1. (<a title=\"LAG-3 as a dual-modulator of neuroimmune surveillance and \u03b1-synuclein propagation in Parkinson\u2019s disease and Lewy body dementia | Discover Neuroscience | Springer Nature Link\" href=\"https:\/\/link.springer.com\/article\/10.1186\/s13064-026-00259-4?utm_source=chatgpt.com\">Springer<\/a>)<\/p>\n<p>\u10d4\u10e1 \u10d2\u10d0\u10dc\u10e1\u10ee\u10d5\u10d0\u10d5\u10d4\u10d1\u10d0 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1: \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10d7\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10de\u10d4\u10e0\u10e1\u10de\u10d4\u10e5\u10e2\u10d8\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10de\u10d4\u10e0\u10e1\u10de\u10d4\u10e5\u10e2\u10d8\u10e3\u10da\u10d8 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8 \u10d3\u10d0 \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10d4\u10e0\u10d7\u10d8 \u10d3\u10d0 \u10d8\u10d2\u10d8\u10d5\u10d4 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<h2>\u10e1\u10d0\u10e5\u10d0\u10e0\u10d7\u10d5\u10d4\u10da\u10dd\u10e1 \u10d9\u10dd\u10dc\u10e2\u10d4\u10e5\u10e1\u10e2\u10d8<\/h2>\n<p>\u10e1\u10d0\u10e5\u10d0\u10e0\u10d7\u10d5\u10d4\u10da\u10dd\u10e1\u10d7\u10d5\u10d8\u10e1 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d9\u10d8\u10d7\u10ee\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10db\u10dd\u10db\u10e1\u10d0\u10ee\u10e3\u10e0\u10d4\u10d1\u10d8\u10e1, \u10d8\u10e1\u10d4 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d8 \u10db\u10dd\u10d5\u10da\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e0\u10d4\u10d0\u10d1\u10d8\u10da\u10d8\u10e2\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d7\u10d5\u10d0\u10da\u10e1\u10d0\u10d6\u10e0\u10d8\u10e1\u10d8\u10d7. \u10db\u10e1\u10dd\u10e4\u10da\u10d8\u10dd \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10dd\u10e0\u10d2\u10d0\u10dc\u10d8\u10d6\u10d0\u10ea\u10d8\u10d0 \u10ee\u10d0\u10d6\u10e1 \u10e3\u10e1\u10d5\u10d0\u10db\u10e1, \u10e0\u10dd\u10db \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d0\u10e0\u10d7\u10d5\u10d0\u10e8\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e0\u10dd\u10da\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10f0\u10e5\u10dd\u10dc\u10d3\u10d4\u10e1 \u10e1\u10d0\u10d7\u10d0\u10dc\u10d0\u10d3\u10dd\u10d3 \u10db\u10dd\u10db\u10d6\u10d0\u10d3\u10d4\u10d1\u10e3\u10da \u10de\u10d8\u10e0\u10d5\u10d4\u10da\u10d0\u10d3\u10d8 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10de\u10d4\u10e0\u10e1\u10dd\u10dc\u10d0\u10da\u10e1, \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10d8\u10db \u10d2\u10d0\u10e0\u10d4\u10db\u10dd\u10e8\u10d8, \u10e1\u10d0\u10d3\u10d0\u10ea \u10e1\u10de\u10d4\u10ea\u10d8\u10d0\u10da\u10d8\u10d6\u10d4\u10d1\u10e3\u10da\u10d8 \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10db\u10dd\u10db\u10e1\u10d0\u10ee\u10e3\u10e0\u10d4\u10d1\u10d0 \u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10e3\u10da\u10d8\u10d0. (<a title=\"Parkinson disease\" href=\"https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/parkinson-disease?utm_source=chatgpt.com\">World Health Organization<\/a>)<\/p>\n<p>\u10e1\u10d0\u10e5\u10d0\u10e0\u10d7\u10d5\u10d4\u10da\u10dd\u10e1 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10e1\u10d8\u10e1\u10e2\u10d4\u10db\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d0\u10ee\u10d0\u10da\u10d8 \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10db\u10d9\u10d0\u10e4\u10d8\u10dd \u10d6\u10e6\u10d5\u10e0\u10d8\u10e1 \u10d2\u10d0\u10d5\u10da\u10d4\u10d1\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10de\u10e0\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1. \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10e1 \u10d0\u10e0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10d4\u10e5\u10db\u10dc\u10d0\u10e1 \u10e8\u10d7\u10d0\u10d1\u10d4\u10ed\u10d3\u10d8\u10da\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db \u10d9\u10d8\u10d1\u10dd\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8\u10e1 \u10d7\u10d5\u10d8\u10d7\u10dc\u10d4\u10d1\u10e3\u10e0\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10db\u10d4\u10d7\u10dd\u10d3\u10d8\u10d0.<\/p>\n<p>\u10dc\u10d4\u10d1\u10d8\u10e1\u10db\u10d8\u10d4\u10e0\u10d8 \u10d0\u10e1\u10d4\u10d7\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10db\u10dd\u10d8\u10d7\u10ee\u10dd\u10d5\u10e1 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d0\u10e1, \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1 \u10db\u10d0\u10e0\u10d4\u10d2\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d4\u10da \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0\u10e1, \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d8\u10e1 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10e1 \u10d3\u10d0 \u10e1\u10de\u10d4\u10ea\u10d8\u10d0\u10da\u10d8\u10e1\u10e2\u10d8\u10e1 \u10d2\u10d0\u10d3\u10d0\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8\u10da\u10d4\u10d1\u10d0\u10e1.<\/p>\n<p>\u10e1\u10d0\u10d4\u10e0\u10d7\u10d0\u10e8\u10dd\u10e0\u10d8\u10e1\u10dd \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10d7\u10d0\u10dc\u10d0\u10db\u10e8\u10e0\u10dd\u10db\u10da\u10dd\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d6\u10d4 \u10d3\u10d0\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10d8\u10e1 \u10d2\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d4\u10d1\u10d0 \u10e1\u10d0\u10e5\u10d0\u10e0\u10d7\u10d5\u10d4\u10da\u10dd\u10e1\u10d7\u10d5\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10da\u10dd\u10d1\u10d0\u10d0. \u10d0\u10db \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d8\u10d7 \u10d0\u10d9\u10d0\u10d3\u10d4\u10db\u10d8\u10e3\u10e0\u10d8 \u10e0\u10d4\u10e1\u10e3\u10e0\u10e1\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10ea\u10dc\u10dd\u10d1\u10d0 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1, [<a href=\"http:\/\/www.gmj.xn--ge]--3cruc\/\">www.gmj.ge]-\u10d8\u10e1<\/a> \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10e1\u10d8\u10d5\u10e0\u10ea\u10d4\u10e8\u10d8, \u10ee\u10dd\u10da\u10dd \u10ee\u10d0\u10e0\u10d8\u10e1\u10ee\u10d8\u10e1, \u10e1\u10e2\u10d0\u10dc\u10d3\u10d0\u10e0\u10e2\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d4\u10e0\u10e2\u10d8\u10e4\u10d8\u10ea\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d9\u10d8\u10d7\u10ee\u10d4\u10d1\u10d6\u10d4 \u2014 [<a href=\"http:\/\/www.certificate.xn--ge]--3cruc\/\">www.certificate.ge]-\u10d8\u10e1<\/a> \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1 \u10e0\u10d4\u10e1\u10e3\u10e0\u10e1\u10d4\u10d1\u10e8\u10d8.<\/p>\n<p>\u10e1\u10d0\u10d6\u10dd\u10d2\u10d0\u10d3\u10dd\u10d4\u10d1\u10e0\u10d8\u10d5\u10d8 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10d7\u10d5\u10d0\u10da\u10e1\u10d0\u10d6\u10e0\u10d8\u10e1\u10d8\u10d7 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10d8\u10dc\u10e4\u10dd\u10e0\u10db\u10d0\u10ea\u10d8\u10d8\u10e1 \u10e1\u10ec\u10dd\u10e0\u10d0\u10d3 \u10d2\u10d0\u10d3\u10db\u10dd\u10ea\u10d4\u10db\u10d0. [<a href=\"http:\/\/www.publichealth.xn--ge]--3cruc\/\">www.publichealth.ge]-\u10d8\u10e1<\/a> \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d8 \u10e1\u10d0\u10d6\u10dd\u10d2\u10d0\u10d3\u10dd\u10d4\u10d1\u10e0\u10d8\u10d5\u10d8 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10de\u10da\u10d0\u10e2\u10e4\u10dd\u10e0\u10db\u10d4\u10d1\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc \u10e0\u10dd\u10da\u10e1 \u10d0\u10e1\u10e0\u10e3\u10da\u10d4\u10d1\u10e1 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d6\u10d4 \u10d3\u10d0\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10dc\u10e4\u10dd\u10e0\u10db\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0\u10e8\u10d8.<\/p>\n<p>\u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10e1\u10d0\u10dc\u10d3\u10dd \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10d8\u10dc\u10e4\u10dd\u10e0\u10db\u10d0\u10ea\u10d8\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10d8\u10e1\u10d4\u10d7\u10d8 \u10ec\u10e7\u10d0\u10e0\u10dd\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10e1 \u10d0\u10e0 \u10d0\u10ed\u10d0\u10e0\u10d1\u10d4\u10d1\u10e1 \u10d3\u10d0 \u10db\u10d9\u10d0\u10e4\u10d8\u10dd\u10d3 \u10db\u10d8\u10e3\u10d7\u10d8\u10d7\u10d4\u10d1\u10e1, \u10e0\u10d0 \u10d0\u10e0\u10d8\u10e1 \u10e3\u10d9\u10d5\u10d4 \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10d0 \u10e0\u10d0 \u2014 \u10ef\u10d4\u10e0 \u10d9\u10d8\u10d3\u10d4\u10d5 \u10e8\u10d4\u10e1\u10d0\u10e1\u10ec\u10d0\u10d5\u10da\u10d8.<\/p>\n<h2>\u10db\u10d8\u10d7\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0<\/h2>\n<p><strong>\u10db\u10d8\u10d7\u10d8: \u10e3\u10d9\u10d5\u10d4 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10e1\u10d0\u10ea \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e9\u10d4\u10e0\u10d4\u10d1\u10d0 \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0.<\/strong><\/p>\n<p>\u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0: Aplp1-Lag3-\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10e8\u10d8 \u10e9\u10d0\u10e2\u10d0\u10e0\u10d3\u10d0. \u10db\u10d8\u10e1\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10d8 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10d0\u10dc\u10dd\u10d1\u10d0\u10e1 \u10d0\u10e0 \u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e1. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p><strong>\u10db\u10d8\u10d7\u10d8: \u10db\u10d4\u10da\u10d0\u10dc\u10dd\u10db\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8 \u10e3\u10d9\u10d5\u10d4 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1.<\/strong><\/p>\n<p>\u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0: \u10dc\u10d8\u10d5\u10dd\u10da\u10e3\u10db\u10d0\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e0\u10d4\u10da\u10d0\u10e2\u10da\u10d8\u10db\u10d0\u10d1\u10d8\u10e1 \u10d9\u10dd\u10db\u10d1\u10d8\u10dc\u10d0\u10ea\u10d8\u10d0 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10d2\u10d0\u10e0\u10d9\u10d5\u10d4\u10e3\u10da\u10d8 \u10db\u10d4\u10da\u10d0\u10dc\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10d0\u10e0\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1. (<a title=\"Search Orphan Drug Designations and Approvals\" href=\"https:\/\/www.accessdata.fda.gov\/scripts\/opdlisting\/oopd\/detailedIndex.cfm?cfgridkey=595017&amp;utm_source=chatgpt.com\">FDA Access Data<\/a>)<\/p>\n<p><strong>\u10db\u10d8\u10d7\u10d8: \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 \u10d4\u10e0\u10d7\u10d8 \u10ea\u10d8\u10da\u10d8\u10e1 \u10de\u10e0\u10dd\u10d1\u10da\u10d4\u10db\u10d0\u10d0.<\/strong><\/p>\n<p>\u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0: \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d1\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d9\u10dd\u10db\u10de\u10dd\u10dc\u10d4\u10dc\u10e2\u10d8\u10d0, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0 \u10db\u10e0\u10d0\u10d5\u10d0\u10da\u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10e3\u10da\u10d8 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d0\u10d0. \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8 \u10d0\u10e1\u10d4\u10d5\u10d4 \u10e8\u10d4\u10d8\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10e1 \u10d2\u10d4\u10dc\u10d4\u10e2\u10d8\u10d9\u10e3\u10e0, \u10e3\u10ef\u10e0\u10d4\u10d3\u10e3\u10da, \u10d8\u10db\u10e3\u10dc\u10e3\u10e0 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d4\u10d1\u10e1.<\/p>\n<p><strong>\u10db\u10d8\u10d7\u10d8: \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10e8\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da\u10d8 90-\u10de\u10e0\u10dd\u10ea\u10d4\u10dc\u10e2\u10d8\u10d0\u10dc\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10dc\u10d8\u10e8\u10dc\u10d0\u10d5\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 90 \u10de\u10e0\u10dd\u10ea\u10d4\u10dc\u10e2\u10d8\u10d7 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8.<\/strong><\/p>\n<p>\u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0: \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10d8 \u10d9\u10dd\u10dc\u10d9\u10e0\u10d4\u10e2\u10e3\u10da \u10e3\u10ef\u10e0\u10d4\u10d3\u10e3\u10da \u10d3\u10d0 \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10e3\u10e0 \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10e1 \u10d4\u10ee\u10d4\u10d1\u10d0. \u10db\u10d0\u10d7\u10d8 \u10de\u10d8\u10e0\u10d3\u10d0\u10de\u10d8\u10e0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10e2\u10d0\u10dc\u10d0 \u10d3\u10d0\u10e3\u10e8\u10d5\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d4\u10e8\u10d4.<\/p>\n<h2>\u10ee\u10e8\u10d8\u10e0\u10d0\u10d3 \u10d3\u10d0\u10e1\u10db\u10e3\u10da\u10d8 \u10d9\u10d8\u10d7\u10ee\u10d5\u10d4\u10d1\u10d8 (Q&amp;A)<\/h2>\n<p><strong>\u10e0\u10d0 \u10d0\u10e0\u10d8\u10e1 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8?<\/strong><\/p>\n<p>\u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8 \u10dc\u10d4\u10e0\u10d5\u10e3\u10da \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e8\u10d8 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10ea\u10d8\u10da\u10d0\u10d0. \u10db\u10d8\u10e1\u10d8 \u10d0\u10e0\u10d0\u10e1\u10ec\u10dd\u10e0\u10d0\u10d3 \u10d3\u10d0\u10d9\u10d4\u10ea\u10d8\u10da\u10d8 \u10d3\u10d0 \u10d0\u10d2\u10e0\u10d4\u10d2\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e4\u10dd\u10e0\u10db\u10d4\u10d1\u10d8 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10d0\u10e1\u10d7\u10d0\u10dc \u10d0\u10e0\u10d8\u10e1 \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8.<\/p>\n<p><strong>\u10e0\u10d0 \u10d0\u10e6\u10db\u10dd\u10d0\u10e9\u10d8\u10dc\u10d4\u10e1 Aplp1-\u10e1\u10d0 \u10d3\u10d0 Lag3-\u10d6\u10d4?<\/strong><\/p>\n<p>\u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db \u10d4\u10e1 \u10dd\u10e0\u10d8 \u10ea\u10d8\u10da\u10d0 \u10d4\u10e0\u10d7\u10db\u10d0\u10dc\u10d4\u10d7\u10d7\u10d0\u10dc \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10e1 \u10d3\u10d0 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10dc\u10d4\u10e0\u10d5\u10e3\u10da \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e8\u10d8 \u10e8\u10d4\u10e6\u10ec\u10d4\u10d5\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10d2\u10d0\u10d3\u10d0\u10ea\u10d4\u10db\u10d0\u10e1 \u10ee\u10d4\u10da\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10e8\u10d8. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p><strong>\u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d7\u10e3 \u10d0\u10e0\u10d0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10dd\u10dc\u10d9\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1?<\/strong><\/p>\n<p>\u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10d0\u10db\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10e1\u10d0\u10d9\u10db\u10d0\u10e0\u10d8\u10e1\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1. \u10d9\u10d8\u10d1\u10dd\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8\u10e1 \u10e1\u10ee\u10d5\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10ea\u10d0\u10da\u10d9\u10d4 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1 \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10d2\u10d0\u10d3\u10d0\u10ec\u10e7\u10d5\u10d4\u10e2\u10d8\u10da\u10d4\u10d1\u10d0\u10e1 \u10db\u10dd\u10d8\u10d7\u10ee\u10dd\u10d5\u10e1.<\/p>\n<p><strong>\u10d0\u10e0\u10d8\u10e1 \u10d7\u10e3 \u10d0\u10e0\u10d0 Lag3-\u10d8\u10e1 \u10e1\u10d0\u10ec\u10d8\u10dc\u10d0\u10d0\u10e6\u10db\u10d3\u10d4\u10d2\u10dd \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8?<\/strong><\/p>\n<p>\u10d0\u10e0\u10d0. \u10d0\u10db \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d8\u10d7 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 \u10ef\u10d4\u10e0 \u10ec\u10d8\u10dc\u10d0\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10e1 \u10d4\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10d0. (<a title=\"LAG-3 as a dual-modulator of neuroimmune surveillance and \u03b1-synuclein propagation in Parkinson\u2019s disease and Lewy body dementia | Discover Neuroscience | Springer Nature Link\" href=\"https:\/\/link.springer.com\/article\/10.1186\/s13064-026-00259-4?utm_source=chatgpt.com\">Springer<\/a>)<\/p>\n<p><strong>\u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10d7\u10e3 \u10d0\u10e0\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d0\u10e9\u10d4\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0?<\/strong><\/p>\n<p>\u10d0\u10db\u10df\u10d0\u10db\u10d0\u10d3 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10dd\u10d3\u10d8\u10e4\u10d8\u10ea\u10d8\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10e1 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d0\u10d3 \u10d0\u10e9\u10d4\u10e0\u10d4\u10d1\u10e1 \u10d0\u10dc \u10d0\u10dc\u10d4\u10da\u10d4\u10d1\u10e1, \u10d0\u10e0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1. \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3\u10d0\u10d3 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10e1 \u10d4\u10db\u10e1\u10d0\u10ee\u10e3\u10e0\u10d4\u10d1\u10d0. (<a title=\"Parkinson disease\" href=\"https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/parkinson-disease?utm_source=chatgpt.com\">World Health Organization<\/a>)<\/p>\n<p><strong>\u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10ec\u10e7\u10d5\u10d8\u10e2\u10dd\u10e1 \u10d7\u10e3 \u10d0\u10e0\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10db\u10d0 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10d0\u10ee\u10d0\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd?<\/strong><\/p>\n<p>\u10d0\u10e0\u10d0. \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10d7\u10d8 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d0 \u10d0\u10e0 \u10ec\u10d0\u10e0\u10db\u10dd\u10d0\u10d3\u10d2\u10d4\u10dc\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10ea\u10d5\u10da\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d0\u10ea\u10d8\u10d0\u10e1. \u10dc\u10d4\u10d1\u10d8\u10e1\u10db\u10d8\u10d4\u10e0\u10d8 \u10ea\u10d5\u10da\u10d8\u10da\u10d4\u10d1\u10d0 \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d7\u10d0\u10dc \u10e8\u10d4\u10d7\u10d0\u10dc\u10ee\u10db\u10d4\u10d1\u10d8\u10d7 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10dc\u10ee\u10dd\u10e0\u10ea\u10d8\u10d4\u10da\u10d3\u10d4\u10e1.<\/p>\n<h2>\u10d3\u10d0\u10e1\u10d9\u10d5\u10dc\u10d0 \u2014 \u10e1\u10d0\u10d6\u10dd\u10d2\u10d0\u10d3\u10dd\u10d4\u10d1\u10e0\u10d8\u10d5\u10d8 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10de\u10d4\u10e0\u10e1\u10de\u10d4\u10e5\u10e2\u10d8\u10d5\u10d8\u10d7<\/h2>\n<p>Aplp1-\u10e1\u10d0 \u10d3\u10d0 Lag3-\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d1\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10e3\u10d9\u10d4\u10d7 \u10d2\u10d0\u10d2\u10d4\u10d1\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10ec\u10d8\u10dc\u10d0\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10dc\u10d0\u10d1\u10d8\u10ef\u10d8\u10d0. \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db \u10d0\u10db \u10ea\u10d8\u10da\u10d4\u10d1\u10d8\u10e1 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0\u10e8\u10d8 \u10e9\u10d0\u10e0\u10d4\u10d5\u10d0\u10db \u10d7\u10d0\u10d2\u10d5\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10e8\u10d8 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10db\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10dc\u10d4\u10d8\u10e0\u10dd\u10d3\u10d4\u10d2\u10d4\u10dc\u10d4\u10e0\u10d0\u10ea\u10d8\u10e3\u10da\u10d8 \u10ea\u10d5\u10da\u10d8\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 \u10e8\u10d4\u10d0\u10db\u10ea\u10d8\u10e0\u10d0. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/p>\n<p>\u10d0\u10db \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d8\u10e1 \u10db\u10d7\u10d0\u10d5\u10d0\u10e0\u10d8 \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d0 \u10d8\u10e1 \u10d0\u10e0\u10d8\u10e1, \u10e0\u10dd\u10db \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10ea\u10d8\u10da\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d8\u10e1 \u10d9\u10dd\u10dc\u10d9\u10e0\u10d4\u10e2\u10e3\u10da\u10d8 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10db\u10dd\u10db\u10d0\u10d5\u10d0\u10da\u10e8\u10d8 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da\u10d8 \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4 \u10d2\u10d0\u10ee\u10d3\u10d4\u10e1. \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10e1\u10d0\u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10dd\u10d0 Lag3, \u10e0\u10d0\u10d3\u10d2\u10d0\u10dc \u10db\u10d8\u10e1\u10d8 \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4 \u10e3\u10d9\u10d5\u10d4 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10dd\u10dc\u10d9\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0 \u10de\u10e0\u10d0\u10e5\u10e2\u10d8\u10d9\u10d0\u10e8\u10d8.<\/p>\n<p>\u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10e7\u10d5\u10d4\u10da\u10d0\u10d6\u10d4 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d6\u10d0\u10d5\u10dc\u10d8\u10da\u10d8 \u10e1\u10d8\u10e4\u10e0\u10d7\u10ee\u10d8\u10da\u10d4\u10d0: \u10db\u10d4\u10da\u10d0\u10dc\u10dd\u10db\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10d3\u10d0 \u10db\u10d8\u10e1\u10d8 \u10d7\u10d5\u10d8\u10d7\u10dc\u10d4\u10d1\u10e3\u10e0\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d3\u10d0\u10e3\u10e8\u10d5\u10d4\u10d1\u10d4\u10da\u10d8\u10d0. \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10d0\u10dc\u10dd\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10e1\u10d0\u10d3\u10d2\u10d4\u10dc\u10d0\u10d3 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10e1\u10de\u10d4\u10ea\u10d8\u10d0\u10da\u10e3\u10e0\u10d0\u10d3 \u10d3\u10d0\u10d2\u10d4\u10d2\u10db\u10d8\u10da\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8.<\/p>\n<p>\u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10de\u10e0\u10d0\u10e5\u10e2\u10d8\u10d9\u10e3\u10da\u10d8 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d0\u10ea\u10d8\u10d0 \u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10e3\u10ea\u10d5\u10da\u10d4\u10da\u10d8\u10d0: \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d8\u10d0\u10d2\u10dc\u10dd\u10e1\u10e2\u10d8\u10d9\u10d0 \u10d3\u10d0 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10e3\u10dc\u10d3\u10d0 \u10d4\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10dd\u10d3\u10d4\u10e1 \u10dc\u10d4\u10d5\u10e0\u10dd\u10da\u10dd\u10d2\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0\u10e1, \u10ee\u10dd\u10da\u10dd \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d8\u10e1 \u10e8\u10d4\u10ea\u10d5\u10da\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10d0\u10ee\u10d0\u10da\u10d8 \u10da\u10d0\u10d1\u10dd\u10e0\u10d0\u10e2\u10dd\u10e0\u10d8\u10e3\u10da\u10d8 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd \u10d0\u10e0 \u10e3\u10dc\u10d3\u10d0 \u10db\u10dd\u10ee\u10d3\u10d4\u10e1.<\/p>\n<p>\u10d0\u10db \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10e1 \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0 \u10ee\u10d4\u10da\u10d8 \u10e8\u10d4\u10e3\u10ec\u10e7\u10dd\u10e1 \u10d0\u10ee\u10d0\u10da\u10d8 \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10f0\u10d8\u10de\u10dd\u10d7\u10d4\u10d6\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d0\u10e1, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10db\u10d8\u10e1\u10d8 \u10e1\u10d0\u10d1\u10dd\u10da\u10dd\u10dd \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10db\u10d0\u10e8\u10d8\u10dc \u10d2\u10d0\u10ee\u10d3\u10d4\u10d1\u10d0 \u10ea\u10dc\u10dd\u10d1\u10d8\u10da\u10d8, \u10d7\u10e3 \u10e8\u10d4\u10db\u10d3\u10d2\u10dd\u10db\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d3\u10d0\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e1 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10d0\u10dc\u10dd\u10d1\u10d0\u10e1, \u10d8\u10e1\u10d4 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d0\u10e1. \u10e1\u10d0\u10d6\u10dd\u10d2\u10d0\u10d3\u10dd\u10d4\u10d1\u10e0\u10d8\u10d5\u10d8 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10e1\u10ec\u10dd\u10e0\u10d4\u10d3 \u10d0\u10e1\u10d4\u10d7\u10d8 \u10d4\u10e2\u10d0\u10de\u10dd\u10d1\u10e0\u10d8\u10d5\u10d8, \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d6\u10d4 \u10d3\u10d0\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d8\u10d3\u10d2\u10dd\u10db\u10d0\u10d0 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8.<\/p>\n<h2>\u10ec\u10e7\u10d0\u10e0\u10dd\u10d4\u10d1\u10d8<\/h2>\n<ol>\n<li>Mao X, Gu H, Kim D, et al. Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein. <em>Nature Communications<\/em>. 2024;15:4663. (<a title=\"Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-49016-3?utm_source=chatgpt.com\">Nature<\/a>)<\/li>\n<li>Mao X, Gu H, Kim D, et al. Author Correction: Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein. <em>Nature Communications<\/em>. 2024;15:6413. (<a title=\"Author Correction: Aplp1 interacts with Lag3 to facilitate transmission of pathologic \u03b1-synuclein | Nature Communications\" href=\"https:\/\/www.nature.com\/articles\/s41467-024-50640-2?utm_source=chatgpt.com\">Nature<\/a>)<\/li>\n<li>World Health Organization. Parkinson disease: Fact sheet. World Health Organization. (<a title=\"Parkinson disease\" href=\"https:\/\/www.who.int\/en\/news-room\/fact-sheets\/detail\/parkinson-disease?utm_source=chatgpt.com\">World Health Organization<\/a>)<\/li>\n<li>World Health Organization. Launch of WHO&#8217;s Parkinson disease technical brief. 14 June 2022. (<a title=\"Launch of WHO's Parkinson disease technical brief\" href=\"https:\/\/www.who.int\/news\/item\/14-06-2022-launch-of-who-s-parkinson-disease-technical-brief?utm_source=chatgpt.com\">World Health Organization<\/a>)<\/li>\n<li>Armstrong MJ, Okun MS. Diagnosis and Treatment of Parkinson Disease: A Review. <em>JAMA<\/em>. 2020.<\/li>\n<li>National Institute on Aging. Parkinson&#8217;s Disease: Causes, Symptoms, and Treatments. National Institutes of Health. (<a title=\"Parkinson\u2019s Disease: Causes, Symptoms, and Treatments | National Institute on Aging\" href=\"https:\/\/www.nia.nih.gov\/health\/parkinsons-disease\/parkinsons-disease-causes-symptoms-and-treatments?pubDate=20250515&amp;utm_source=chatgpt.com\">National Institute on Aging<\/a>)<\/li>\n<li>National Institute of Neurological Disorders and Stroke. Parkinson&#8217;s Disease: Research, Challenges, Progress and Promise. National Institutes of Health. (<a title=\"Parkinson's Disease | National Institute of Neurological Disorders and Stroke\" href=\"https:\/\/www.ninds.nih.gov\/current-research\/focus-disorders\/parkinsons-disease-research\/parkinsons-disease-challenges-progress-and-promise?utm_source=chatgpt.com\">NINDS<\/a>)<\/li>\n<li>Fox SH, Katzenschlager R, Lim SY, et al. International Parkinson and Movement Disorder Society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson&#8217;s disease. <em>Movement Disorders<\/em>. 2018. (<a title=\"International Parkinson and movement disorder society evidence-based medicine review: Update on treatments for the motor symptoms of Parkinson's disease - PubMed\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29570866\/?utm_source=chatgpt.com\">PubMed<\/a>)<\/li>\n<li>Pringsheim T, Jette N, Frolkis A, Steeves TDL. The prevalence of Parkinson&#8217;s disease: a systematic review and meta-analysis. <em>Movement Disorders<\/em>. 2014.<\/li>\n<li>U.S. Food and Drug Administration. Nivolumab and relatlimab-rmbw (Opdualag): approved indication. (<a title=\"Search Orphan Drug Designations and Approvals\" href=\"https:\/\/www.accessdata.fda.gov\/scripts\/opdlisting\/oopd\/detailedIndex.cfm?cfgridkey=595017&amp;utm_source=chatgpt.com\">FDA Access Data<\/a>)<\/li>\n<li>LAG-3 as a dual-modulator of neuroimmune surveillance and \u03b1-synuclein propagation in Parkinson\u2019s disease and Lewy body dementia. <em>Discover Neuroscience<\/em>. 2026. (<a title=\"LAG-3 as a dual-modulator of neuroimmune surveillance and \u03b1-synuclein propagation in Parkinson\u2019s disease and Lewy body dementia | Discover Neuroscience | Springer Nature Link\" href=\"https:\/\/link.springer.com\/article\/10.1186\/s13064-026-00259-4?utm_source=chatgpt.com\">Springer<\/a>)<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>\u10dd\u10e0\u10d8 \u10ea\u10d8\u10da\u10d0 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd\u10d0 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d0\u10e8\u10d8 \u10db\u10dd\u10dc\u10d0\u10ec\u10d8\u10da\u10d4\u10dd\u10d1\u10d3\u10d4\u10e1 \u2014 \u10d0\u10ee\u10d0\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4\u10e1 \u10d0\u10d5\u10da\u10d4\u10dc\u10e1 \u10e8\u10d4\u10e1\u10d0\u10d5\u10d0\u10da\u10d8 \u2014 \u10d0\u10dc\u10d0\u10da\u10d8\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10dd\u10db\u10d4\u10dc\u10e2\u10d0\u10e0\u10d8 \u10de\u10d0\u10e0\u10d9\u10d8\u10dc\u10e1\u10dd\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7\u10d8 \u10e7\u10d5\u10d4\u10da\u10d0\u10d6\u10d4 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d0 \u10d3\u10e6\u10d4\u10e1 \u10d0\u10e0\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10e3\u10d9\u10d5\u10d4 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e1\u10d8\u10db\u10de\u10e2\u10dd\u10db\u10d4\u10d1\u10d8\u10e1 \u10d9\u10dd\u10dc\u10e2\u10e0\u10dd\u10da\u10d8, \u10d0\u10e0\u10d0\u10db\u10d4\u10d3 \u10d8\u10db \u10d1\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d0\u10d0, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10dc\u10d4\u10e0\u10d5\u10e3\u10da\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10de\u10e0\u10dd\u10d2\u10e0\u10d4\u10e1\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10e4\u10e3\u10eb\u10d5\u10d4\u10da\u10e1 \u10e5\u10db\u10dc\u10d8\u10e1. \u10e1\u10ec\u10dd\u10e0\u10d4\u10d3 \u10d0\u10db \u10d9\u10dd\u10dc\u10e2\u10d4\u10e5\u10e1\u10e2\u10e8\u10d8 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10e3\u10da \u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10e1 \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1 \u10d0\u10da\u10e4\u10d0-\u10e1\u10d8\u10dc\u10e3\u10d9\u10da\u10d4\u10d8\u10dc\u10d8\u10e1 \u10de\u10d0\u10d7\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10e4\u10dd\u10e0\u10db\u10d4\u10d1\u10d8\u10e1 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":89185,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_sheni_byline":"giorgi","footnotes":""},"categories":[272],"tags":[11777],"class_list":["post-89176","post","type-post","status-publish","format-standard","has-post-thumbnail","category-272","tag-11777"],"_links":{"self":[{"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/posts\/89176","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/comments?post=89176"}],"version-history":[{"count":1,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/posts\/89176\/revisions"}],"predecessor-version":[{"id":89187,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/posts\/89176\/revisions\/89187"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/media\/89185"}],"wp:attachment":[{"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/media?parent=89176"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/categories?post=89176"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/tags?post=89176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}