{"id":88141,"date":"2026-09-16T16:15:26","date_gmt":"2026-09-16T12:15:26","guid":{"rendered":"https:\/\/sheniekimi.ge\/ambebi\/?p=88141"},"modified":"2026-09-25T20:44:12","modified_gmt":"2026-09-25T16:44:12","slug":"%e1%83%9b%e1%83%94%e1%83%aa%e1%83%9c%e1%83%98%e1%83%94%e1%83%a0%e1%83%94%e1%83%91%e1%83%9b%e1%83%90-%e1%83%90%e1%83%a6%e1%83%9b%e1%83%9d%e1%83%90%e1%83%a9%e1%83%98%e1%83%9c%e1%83%94%e1%83%a1-%e1%83%94","status":"publish","type":"post","link":"https:\/\/sheniekimi.ge\/ambebi\/%e1%83%9b%e1%83%94%e1%83%aa%e1%83%9c%e1%83%98%e1%83%94%e1%83%a0%e1%83%94%e1%83%91%e1%83%9b%e1%83%90-%e1%83%90%e1%83%a6%e1%83%9b%e1%83%9d%e1%83%90%e1%83%a9%e1%83%98%e1%83%9c%e1%83%94%e1%83%a1-%e1%83%94\/","title":{"rendered":"\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10db\u10d0 \u10d0\u10e6\u10db\u10dd\u10d0\u10e9\u10d8\u10dc\u10d4\u10e1 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10d2\u10d6\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d0\u10e1\u10d0\u10d9\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10d0\u10e1\u10d8\u10e1 \u10d9\u10d0\u10e0\u10d2\u10d5\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d0\u10ee\u10d0\u10da \u10db\u10d4\u10d7\u10dd\u10d3\u10d4\u10d1\u10d0\u10db\u10d3\u10d4 \u10db\u10d8\u10d2\u10d5\u10d8\u10e7\u10d5\u10d0\u10dc\u10d3\u10d4\u10e1"},"content":{"rendered":"<h1>GPR133-\u10d8\u10e1 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d0\u10db \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0 \u10d2\u10d0\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d0 \u2014 \u10d0\u10ee\u10d0\u10da\u10d8 \u10db\u10d8\u10d3\u10d2\u10dd\u10db\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3<\/h1>\n<h2>\u10e8\u10d4\u10e1\u10d0\u10d5\u10d0\u10da\u10d8 \u2014 \u10d0\u10dc\u10d0\u10da\u10d8\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10dd\u10db\u10d4\u10dc\u10e2\u10d0\u10e0\u10d8<\/h2>\n<p><strong><a href=\"https:\/\/sheniekimi.ge\/2026\/09\/02\/osteoporosis-drug-spinal-disc-degeneration\/\" target=\"_blank\" rel=\"noopener\">\u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8<\/a> \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d0\u10e1\u10d0\u10d9\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10d0, \u10e0\u10dd\u10db\u10da\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1\u10d0\u10ea \u10eb\u10d5\u10da\u10d8\u10e1 \u10e1\u10d8\u10db\u10d9\u10d5\u10e0\u10d8\u10d5\u10d4 \u10d3\u10d0 \u10e1\u10d8\u10db\u10e2\u10d9\u10d8\u10ea\u10d4 \u10db\u10ea\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8 \u10d8\u10d6\u10e0\u10d3\u10d4\u10d1\u10d0.<\/strong> \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10e0\u10dd\u10d1\u10da\u10d4\u10db\u10d0 \u10d8\u10e1 \u10d0\u10e0\u10d8\u10e1, \u10e0\u10dd\u10db \u10db\u10d8\u10e1\u10d8 \u10db\u10d8\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4\u10dd\u10d1\u10d0 \u10ee\u10e8\u10d8\u10e0\u10d0\u10d3 \u10e8\u10d4\u10e3\u10db\u10e9\u10dc\u10d4\u10d5\u10d4\u10da\u10d8\u10d0 \u10db\u10d0\u10dc\u10d0\u10db, \u10e1\u10d0\u10dc\u10d0\u10db \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d0 \u10d0\u10e0 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d3\u10d4\u10d1\u10d0. \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10d1\u10d0\u10e0\u10eb\u10d0\u10e7\u10d8\u10e1, \u10ee\u10d4\u10e0\u10ee\u10d4\u10db\u10da\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d0\u10ef\u10d8\u10e1 <a href=\"https:\/\/sheniekimi.ge\/ambebi\/category\/%e1%83%a0%e1%83%a9%e1%83%94%e1%83%95%e1%83%94%e1%83%91%e1%83%98\/%e1%83%94%e1%83%a5%e1%83%98%e1%83%9b%e1%83%98\/\" target=\"_blank\" rel=\"noopener\">\u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d4\u10d1\u10d8<\/a>, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10ee\u10d0\u10dc\u10d3\u10d0\u10d6\u10db\u10e3\u10da \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd\u10e1 \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5 \u10e0\u10d4\u10d0\u10d1\u10d8\u10da\u10d8\u10e2\u10d0\u10ea\u10d8\u10d0\u10e1\u10d7\u10d0\u10dc, \u10d3\u10d0\u10db\u10dd\u10e3\u10d9\u10d8\u10d3\u10d4\u10d1\u10da\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d9\u10d0\u10e0\u10d2\u10d5\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0 \u10ef\u10d0\u10dc\u10db\u10e0\u10d7\u10d4\u10da\u10dd\u10d1\u10d8\u10e1 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc \u10d2\u10d0\u10e3\u10d0\u10e0\u10d4\u10e1\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc.<\/p>\n<p>\u10db\u10e1\u10dd\u10e4\u10da\u10d8\u10dd\u10e8\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10e7\u10d8\u10e4\u10d4\u10dd\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d4\u10d1\u10d8\u10e1 \u10e2\u10d5\u10d8\u10e0\u10d7\u10d8 \u10d8\u10d6\u10e0\u10d3\u10d4\u10d1\u10d0 \u10db\u10dd\u10e1\u10d0\u10ee\u10da\u10d4\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d1\u10d4\u10e0\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3. \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10db\u10e1\u10dd\u10e4\u10da\u10d8\u10dd \u10dd\u10e0\u10d2\u10d0\u10dc\u10d8\u10d6\u10d0\u10ea\u10d8\u10d8\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8\u10d7, 2019 \u10ec\u10d4\u10da\u10e1 \u10db\u10e1\u10dd\u10e4\u10da\u10d8\u10dd\u10e8\u10d8 178 \u10db\u10d8\u10da\u10d8\u10dd\u10dc\u10d8 \u10d0\u10ee\u10d0\u10da\u10d8 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d0 \u10d3\u10d0\u10e4\u10d8\u10e5\u10e1\u10d8\u10e0\u10d3\u10d0, \u10e0\u10d0\u10ea 1990 \u10ec\u10d4\u10da\u10d7\u10d0\u10dc \u10e8\u10d4\u10d3\u10d0\u10e0\u10d4\u10d1\u10d8\u10d7 33.4 \u10de\u10e0\u10dd\u10ea\u10d4\u10dc\u10e2\u10d8\u10d7 \u10db\u10d4\u10e2\u10d8 \u10d8\u10e7\u10dd. \u10d0\u10e1\u10d0\u10d9\u10dd\u10d5\u10d0\u10dc \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d4\u10d1\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10dc\u10d0\u10ec\u10d8\u10da\u10d8 \u10d3\u10d0\u10d1\u10d0\u10da\u10d8 \u10d4\u10dc\u10d4\u10e0\u10d2\u10d8\u10d8\u10e1 \u10e2\u10e0\u10d0\u10d5\u10db\u10d0\u10e1 \u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0, \u10db\u10d0\u10d7 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10e9\u10d5\u10d4\u10e3\u10da\u10d4\u10d1\u10e0\u10d8\u10d5 \u10d3\u10d0\u10ea\u10d4\u10db\u10d0\u10e1 \u10e1\u10d0\u10d9\u10e3\u10d7\u10d0\u10e0\u10d8 \u10e1\u10d8\u10db\u10d0\u10e6\u10da\u10d8\u10d3\u10d0\u10dc.<\/p>\n<p>\u10d0\u10db \u10e4\u10dd\u10dc\u10d6\u10d4 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10e1\u10d0\u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10dd\u10d0 \u10d0\u10ee\u10d0\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10db\u10d0\u10ea \u10e7\u10e3\u10e0\u10d0\u10d3\u10e6\u10d4\u10d1\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e8\u10d8 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da GPR133-\u10d8\u10e1 \u10e1\u10d0\u10ee\u10d4\u10da\u10d8\u10d7 \u10ea\u10dc\u10dd\u10d1\u10d8\u10da \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10dd\u10e0\u10d6\u10d4 \u10d2\u10d0\u10d3\u10d0\u10d8\u10e2\u10d0\u10dc\u10d0. \u10db\u10d9\u10d5\u10da\u10d4\u10d5\u10e0\u10d4\u10d1\u10db\u10d0 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10e1, \u10e0\u10dd\u10db \u10d0\u10db \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10dd\u10e0\u10d8\u10e1 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d0 \u10dc\u10d0\u10d4\u10e0\u10d7 AP503-\u10d8\u10d7 \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0\u10e1 \u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d4\u10d1\u10d3\u10d0 \u10d3\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10d9\u10d0\u10e0\u10d2\u10d5\u10d0\u10e1 \u10d0\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d3\u10d0.<\/p>\n<p>\u10d7\u10e3\u10db\u10ea\u10d0 \u10d0\u10db \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d0 \u10e1\u10ec\u10dd\u10e0\u10d0\u10d3 \u10e3\u10dc\u10d3\u10d0 \u10d2\u10d0\u10dc\u10d8\u10db\u10d0\u10e0\u10e2\u10dd\u10e1: \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10ef\u10d4\u10e0 \u10d0\u10e0 \u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db AP503 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10d8 \u10d0\u10dc \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d0\u10d0. \u10db\u10d8\u10e1\u10d8 \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10d0\u10da\u10d8 \u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10ec\u10d8\u10dc\u10d0\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10d3\u10dd\u10dc\u10d4\u10d6\u10d4\u10d0 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10da\u10d8.<\/p>\n<h2>\u10de\u10e0\u10dd\u10d1\u10da\u10d4\u10db\u10d8\u10e1 \u10d0\u10e6\u10ec\u10d4\u10e0\u10d0<\/h2>\n<p>\u10eb\u10d5\u10d0\u10da\u10d8 \u10ea\u10dd\u10ea\u10ee\u10d0\u10da\u10d8 \u10e5\u10e1\u10dd\u10d5\u10d8\u10da\u10d8\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10db\u10d7\u10d4\u10da\u10d8 \u10e1\u10d8\u10ea\u10dd\u10ea\u10ee\u10da\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10db\u10e3\u10d3\u10db\u10d8\u10d5\u10d0\u10d3 \u10d2\u10d0\u10dc\u10d0\u10ee\u10da\u10d3\u10d4\u10d1\u10d0. \u10d0\u10db \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10e1 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e0\u10d4\u10db\u10dd\u10d3\u10d4\u10da\u10d8\u10e0\u10d4\u10d1\u10d0 \u10d4\u10ec\u10dd\u10d3\u10d4\u10d1\u10d0. \u10eb\u10d5\u10d4\u10da \u10d0\u10dc \u10d3\u10d0\u10d6\u10d8\u10d0\u10dc\u10d4\u10d1\u10e3\u10da \u10eb\u10d5\u10da\u10dd\u10d5\u10d0\u10dc \u10e5\u10e1\u10dd\u10d5\u10d8\u10da\u10e1 \u10dd\u10e1\u10e2\u10d4\u10dd\u10d9\u10da\u10d0\u10e1\u10e2\u10d4\u10d1\u10d8 \u10e8\u10da\u10d8\u10d0\u10dc, \u10ee\u10dd\u10da\u10dd \u10d0\u10ee\u10d0\u10da \u10e5\u10e1\u10dd\u10d5\u10d8\u10da\u10e1 \u10dd\u10e1\u10e2\u10d4\u10dd\u10d1\u10da\u10d0\u10e1\u10e2\u10d4\u10d1\u10d8 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10d0\u10dc. \u10dd\u10e1\u10e2\u10d4\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8 \u10d9\u10d8 \u10d0\u10db \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d8\u10e1 \u10e0\u10d4\u10d2\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d0\u10e8\u10d8 \u10db\u10dd\u10dc\u10d0\u10ec\u10d8\u10da\u10d4\u10dd\u10d1\u10d4\u10dc. \u10ef\u10d0\u10dc\u10db\u10e0\u10d7\u10d4\u10da \u10dd\u10e0\u10d2\u10d0\u10dc\u10d8\u10d6\u10db\u10e8\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10e8\u10da\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d9\u10d5\u10d4\u10e3\u10da\u10d8 \u10d1\u10d0\u10da\u10d0\u10dc\u10e1\u10d8 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1.<\/p>\n<p>\u10d0\u10e1\u10d0\u10d9\u10d8\u10e1 \u10db\u10d0\u10e2\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3 \u10d4\u10e1 \u10d1\u10d0\u10da\u10d0\u10dc\u10e1\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10e8\u10d4\u10d8\u10ea\u10d5\u10d0\u10da\u10dd\u10e1. \u10e0\u10dd\u10d3\u10d4\u10e1\u10d0\u10ea \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10e8\u10da\u10d0 \u10db\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0\u10e1 \u10d0\u10e6\u10d4\u10db\u10d0\u10e2\u10d4\u10d1\u10d0, \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10db\u10e2\u10d9\u10d8\u10ea\u10d4 \u10db\u10ea\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0. \u10e1\u10ec\u10dd\u10e0\u10d4\u10d3 \u10d0\u10e1\u10d4\u10d7\u10d8 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d4\u10d1\u10d8 \u10ec\u10d0\u10e0\u10db\u10dd\u10d0\u10d3\u10d2\u10d4\u10dc\u10e1 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d4\u10d1\u10d8\u10e1 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10e1.<\/p>\n<p>\u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10db\u10d0\u10e0\u10d7\u10d5\u10d8\u10e1 \u10d7\u10d0\u10dc\u10d0\u10db\u10d4\u10d3\u10e0\u10dd\u10d5\u10d4 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10d8\u10d0 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10da\u10d0\u10d3, \u10d7\u10e3\u10db\u10ea\u10d0 \u10e7\u10d5\u10d4\u10da\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d4\u10e0\u10d7\u10d8 \u10d3\u10d0 \u10d8\u10d2\u10d8\u10d5\u10d4 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10e4\u10d4\u10e0\u10d8\u10e1\u10d8. \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10e1 \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10e8\u10da\u10d8\u10e1 \u10e8\u10d4\u10db\u10d0\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 \u10d3\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10e1 \u10db\u10d0\u10e1\u10e2\u10d8\u10db\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10d7\u10d0 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0\u10ea \u10d8\u10dc\u10d3\u10d8\u10d5\u10d8\u10d3\u10e3\u10d0\u10da\u10e3\u10e0\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0\u10e1 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10e1. \u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d0\u10d3, \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d2\u10d0\u10d8\u10d3\u10da\u10d0\u10d8\u10dc\u10d4\u10d1\u10d8 \u10d1\u10d8\u10e1\u10e4\u10dd\u10e1\u10e4\u10dd\u10dc\u10d0\u10e2\u10d4\u10d1\u10e1 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7 \u10e1\u10d0\u10ec\u10e7\u10d8\u10e1 \u10d5\u10d0\u10e0\u10d8\u10d0\u10dc\u10e2\u10d0\u10d3 \u10d2\u10d0\u10dc\u10d8\u10ee\u10d8\u10da\u10d0\u10d5\u10e1, \u10ee\u10dd\u10da\u10dd \u10eb\u10d0\u10da\u10d8\u10d0\u10dc \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10e1 \u10db\u10d0\u10e1\u10e2\u10d8\u10db\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10ee\u10d8\u10da\u10d5\u10d0\u10ea.<\/p>\n<p>\u10d0\u10db\u10d8\u10e2\u10dd\u10db \u10d0\u10ee\u10d0\u10da\u10d8 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d0\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d0 \u10d0\u10e5\u10d5\u10e1. \u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d8 \u10ea\u10d3\u10d8\u10da\u10dd\u10d1\u10d4\u10dc \u10d8\u10de\u10dd\u10d5\u10dd\u10dc \u10d8\u10e1\u10d4\u10d7\u10d8 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d4\u10d1\u10d8, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10e3\u10e8\u10e3\u10d0\u10da\u10dd\u10d3 \u10d2\u10d0\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d4\u10d1\u10e1 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0\u10e1 \u10d3\u10d0 \u10de\u10d0\u10e0\u10d0\u10da\u10d4\u10da\u10e3\u10e0\u10d0\u10d3 \u10e8\u10d4\u10d0\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10e1 \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10e8\u10da\u10d0\u10e1.<\/p>\n<h2>\u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10d3\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d0\u10dc\u10d0\u10da\u10d8\u10d6\u10d8<\/h2>\n<p>\u10d0\u10ee\u10d0\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10e7\u10e3\u10e0\u10d0\u10d3\u10e6\u10d4\u10d1\u10d8\u10e1 \u10ea\u10d4\u10dc\u10e2\u10e0\u10e8\u10d8\u10d0 GPR133, \u10e0\u10dd\u10db\u10d4\u10da\u10e1\u10d0\u10ea \u10d0\u10e1\u10d4\u10d5\u10d4 ADGRD1 \u10d4\u10ec\u10dd\u10d3\u10d4\u10d1\u10d0. \u10d8\u10e1 \u10db\u10d8\u10d4\u10d9\u10e3\u10d7\u10d5\u10dc\u10d4\u10d1\u10d0 \u10d0\u10d3\u10f0\u10d4\u10d6\u10d8\u10e3\u10e0 G-\u10ea\u10d8\u10da\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10dd\u10e0\u10d4\u10d1\u10e1 \u2014 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10e1 \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10d0\u10d6\u10d4 \u10d2\u10d0\u10dc\u10da\u10d0\u10d2\u10d4\u10d1\u10e3\u10da \u10ea\u10d8\u10da\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10d2\u10d0\u10e0\u10d4 \u10e1\u10d8\u10d2\u10dc\u10d0\u10da\u10d4\u10d1\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10e1 \u10e8\u10d8\u10d2\u10dc\u10d8\u10d7 \u10db\u10d8\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4 \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d4\u10d1\u10d7\u10d0\u10dc \u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10d4\u10dc.<\/p>\n<p>\u10db\u10d9\u10d5\u10da\u10d4\u10d5\u10e0\u10d4\u10d1\u10db\u10d0 \u10d3\u10d0\u10d0\u10d3\u10d2\u10d8\u10dc\u10d4\u10e1, \u10e0\u10dd\u10db GPR133-\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e0\u10e6\u10d5\u10d4\u10d5\u10d0 \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10d0\u10e1\u10d8\u10e1 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1 \u10d8\u10ec\u10d5\u10d4\u10d5\u10d3\u10d0. \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d8\u10e7\u10dd \u10d8\u10e1 \u10e4\u10d0\u10e5\u10e2\u10d8, \u10e0\u10dd\u10db \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10dd\u10e0\u10d8\u10e1 \u10d3\u10d4\u10e4\u10d8\u10ea\u10d8\u10e2\u10d8 \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e6\u10db\u10dd\u10e9\u10dc\u10d3\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10d1\u10da\u10d0\u10e1\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e5\u10d5\u10d4\u10d8\u10d7\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d3\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10e8\u10da\u10d0\u10e8\u10d8 \u10db\u10dd\u10dc\u10d0\u10ec\u10d8\u10da\u10d4 \u10dd\u10e1\u10e2\u10d4\u10dd\u10d9\u10da\u10d0\u10e1\u10e2\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1 \u10d6\u10e0\u10d3\u10d0\u10e1\u10d7\u10d0\u10dc.<\/p>\n<p>\u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8 \u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d9\u10e3\u10e0 \u10d3\u10d0\u10e2\u10d5\u10d8\u10e0\u10d7\u10d5\u10d0\u10e1. \u10eb\u10d5\u10d0\u10da\u10d8 \u10db\u10e3\u10d3\u10db\u10d8\u10d5\u10d0\u10d3 \u10e0\u10d4\u10d0\u10d2\u10d8\u10e0\u10d4\u10d1\u10e1 \u10db\u10dd\u10eb\u10e0\u10d0\u10dd\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10d3\u10d0\u10e2\u10d5\u10d8\u10e0\u10d7\u10d5\u10d0\u10d6\u10d4. \u10db\u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10e0\u10d7\u10d0 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8\u10d7, GPR133-\u10d8\u10e1 \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d0 \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d9\u10e3\u10e0 \u10eb\u10d0\u10da\u10d4\u10d1\u10d7\u10d0\u10dc, \u10d8\u10e1\u10d4 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1 \u10e3\u10e0\u10d7\u10d8\u10d4\u10e0\u10d7\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc. \u10d4\u10e1 \u10e1\u10d8\u10d2\u10dc\u10d0\u10da\u10d4\u10d1\u10d8 \u10e1\u10d0\u10d1\u10dd\u10da\u10dd\u10dd\u10d3 \u10ee\u10d4\u10da\u10e1 \u10e3\u10ec\u10e7\u10dd\u10d1\u10e1 \u10d8\u10db \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db\u10da\u10d4\u10d1\u10d8\u10ea \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0\u10e1 \u10d0\u10e0\u10d4\u10d2\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10e1.<\/p>\n<p>\u10d0\u10db \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10e8\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d0\u10e6\u10db\u10dd\u10e9\u10dc\u10d3\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10e8\u10d8\u10d3\u10d0 \u10ea\u10d8\u10d9\u10da\u10e3\u10e0\u10d8 \u10d0\u10d3\u10d4\u10dc\u10dd\u10d6\u10d8\u10dc\u10db\u10dd\u10dc\u10dd\u10e4\u10dd\u10e1\u10e4\u10d0\u10e2\u10d8\u10e1 \u10e1\u10d8\u10d2\u10dc\u10d0\u10da\u10d8\u10d6\u10d0\u10ea\u10d8\u10d0 \u10d3\u10d0 \u10d1\u10d4\u10e2\u10d0-\u10d9\u10d0\u10e2\u10d4\u10dc\u10d8\u10dc\u10d8\u10e1 \u10d2\u10d6\u10d8\u10e1 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d0. \u10db\u10d0\u10e0\u10e2\u10d8\u10d5\u10d0\u10d3 \u10e0\u10dd\u10db \u10d5\u10d7\u10e5\u10d5\u10d0\u10d7, GPR133-\u10d8\u10e1 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d0\u10db \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10db\u10e5\u10db\u10dc\u10d4\u10da\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d8\u10e4\u10d4\u10e0\u10d4\u10dc\u10ea\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10dd\u10dc\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10db\u10ee\u10d0\u10e0\u10d3\u10d0\u10db\u10ed\u10d4\u10e0\u10d8 \u10e1\u10d8\u10d2\u10dc\u10d0\u10da\u10d4\u10d1\u10d8 \u10d2\u10d0\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d0.<\/p>\n<p>\u10e8\u10d4\u10db\u10d3\u10d4\u10d2 \u10db\u10d9\u10d5\u10da\u10d4\u10d5\u10e0\u10d4\u10d1\u10db\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10e1 AP503 \u2014 \u10db\u10ea\u10d8\u10e0\u10d4 \u10db\u10dd\u10da\u10d4\u10d9\u10e3\u10da\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea GPR133-\u10d8\u10e1 \u10e8\u10d4\u10e0\u10e9\u10d4\u10d5\u10d8\u10d7 \u10d2\u10d0\u10db\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10da\u10d0\u10d3 \u10e8\u10d4\u10d8\u10e5\u10db\u10dc\u10d0. \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10db\u10d8\u10e1\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10dd\u10ea\u10e3\u10da\u10dd\u10d1\u10d0, \u10e2\u10e0\u10d0\u10d1\u10d4\u10d9\u10e3\u10da\u10e3\u10e0\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e0\u10d0\u10dd\u10d3\u10d4\u10dc\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10e1\u10e5\u10d4. \u10d0\u10e1\u10d4\u10d5\u10d4 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10d1\u10da\u10d0\u10e1\u10e2\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10ea\u10d8\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d0\u10dd\u10d3\u10d4\u10dc\u10dd\u10d1\u10d0, \u10ee\u10dd\u10da\u10dd \u10dd\u10e1\u10e2\u10d4\u10dd\u10d9\u10da\u10d0\u10e1\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d0\u10dd\u10d3\u10d4\u10dc\u10dd\u10d1\u10d0 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d3\u10d0.<\/p>\n<p>\u10d4\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0, \u10e0\u10d0\u10d3\u10d2\u10d0\u10dc \u10de\u10dd\u10e2\u10d4\u10dc\u10ea\u10d8\u10e3\u10e0\u10d8 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10e3\u10da\u10d8 \u10db\u10d8\u10d3\u10d2\u10dd\u10db\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10e8\u10da\u10d8\u10e1 \u10e8\u10d4\u10e9\u10d4\u10e0\u10d4\u10d1\u10d0\u10e1 \u10d9\u10d8 \u10d0\u10e0 \u10ea\u10d3\u10d8\u10da\u10dd\u10d1\u10e1, \u10d0\u10e0\u10d0\u10db\u10d4\u10d3 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10e1 \u10d2\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d4\u10d1\u10d0\u10e1\u10d0\u10ea.<\/p>\n<p>\u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10d9\u10d8\u10d3\u10d4\u10d5 \u10e3\u10e4\u10e0\u10dd \u10e1\u10d0\u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10dd \u10dc\u10d0\u10ec\u10d8\u10da\u10d8 \u10d8\u10e7\u10dd \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10db\u10dd\u10d3\u10d4\u10da\u10d8. \u10db\u10d9\u10d5\u10da\u10d4\u10d5\u10e0\u10d4\u10d1\u10db\u10d0 \u10db\u10d3\u10d4\u10d3\u10e0 \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10e1\u10d0\u10d9\u10d5\u10d4\u10e0\u10ea\u10ee\u10d4\u10d4\u10d1\u10d8\u10e1 \u10db\u10dd\u10ea\u10d8\u10da\u10d4\u10d1\u10d8\u10d7 \u10e8\u10d4\u10e5\u10db\u10dc\u10d4\u10e1 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10de\u10dd\u10e1\u10e2\u10db\u10d4\u10dc\u10dd\u10de\u10d0\u10e3\u10d6\u10e3\u10e0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10d9\u10d0\u10e0\u10d2\u10d5\u10d0\u10e1 \u10d2\u10d0\u10e0\u10d9\u10d5\u10d4\u10e3\u10da\u10ec\u10d8\u10da\u10d0\u10d3 \u10db\u10dd\u10d3\u10d4\u10da\u10d8\u10e0\u10d4\u10d1\u10e1. AP503-\u10d8\u10e1 \u10dd\u10d7\u10ee\u10d9\u10d5\u10d8\u10e0\u10d8\u10d0\u10dc\u10db\u10d0 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0\u10db \u10d0\u10db \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10dd\u10ea\u10e3\u10da\u10dd\u10d1\u10d8\u10e1, \u10db\u10d8\u10dc\u10d4\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10e1\u10d8\u10db\u10d9\u10d5\u10e0\u10d8\u10d5\u10d8\u10e1, \u10e5\u10d4\u10e0\u10e5\u10dd\u10d5\u10d0\u10dc\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e1\u10d8\u10e1\u10e5\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10db\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10da\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10e3\u10db\u10ef\u10dd\u10d1\u10d4\u10e1\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10d8\u10ec\u10d5\u10d8\u10d0. \u10d0\u10e1\u10d4\u10d5\u10d4 \u10d2\u10d0\u10d8\u10d6\u10d0\u10e0\u10d3\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10d3\u10d2\u10e0\u10d0\u10d3\u10dd\u10d1\u10d0.<\/p>\n<p>\u10d7\u10e3\u10db\u10ea\u10d0 \u10d7\u10d0\u10d2\u10d5\u10d8\u10e1 \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d8\u10e1 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d0 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1. \u10ec\u10d8\u10dc\u10d0\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10d8\u10db\u10d8\u10e1 \u10d3\u10d0\u10e1\u10d0\u10d3\u10d2\u10d4\u10dc\u10d0\u10d3, \u10db\u10e3\u10e8\u10d0\u10dd\u10d1\u10e1 \u10d7\u10e3 \u10d0\u10e0\u10d0 \u10d9\u10dd\u10dc\u10d9\u10e0\u10d4\u10e2\u10e3\u10da\u10d8 \u10d1\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d6\u10db\u10d8 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10e8\u10d8\u10ea, \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d0\u10d3 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d0 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8, \u10e0\u10d0 \u10d3\u10dd\u10d6\u10d0\u10d0 \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d8 \u10d3\u10d0 \u10e0\u10d0 \u10d2\u10d5\u10d4\u10e0\u10d3\u10d8\u10d7\u10d8 \u10db\u10dd\u10d5\u10da\u10d4\u10dc\u10d4\u10d1\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d3\u10d4\u10e1.<\/p>\n<h2>\u10e1\u10e2\u10d0\u10e2\u10d8\u10e1\u10e2\u10d8\u10d9\u10d0 \u10d3\u10d0 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8<\/h2>\n<p>\u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10e8\u10d8 AP503-\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10e4\u10d0\u10e1\u10d4\u10d1\u10da\u10d0\u10d3 \u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10db\u10d0 \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8 \u10e7\u10dd\u10d5\u10d4\u10da\u10d3\u10e6\u10d8\u10e3\u10e0\u10d0\u10d3, \u10dd\u10d7\u10ee\u10d8 \u10d9\u10d5\u10d8\u10e0\u10d8\u10e1 \u10d2\u10d0\u10dc\u10db\u10d0\u10d5\u10da\u10dd\u10d1\u10d0\u10e8\u10d8 \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10d4\u10e1. \u10ea\u10d0\u10da\u10d9\u10d4\u10e3\u10da \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10d4\u10d1\u10e8\u10d8 \u10dc\u10d0\u10d4\u10e0\u10d7\u10d8\u10e1 \u10d3\u10dd\u10d6\u10d0 \u10e8\u10d4\u10d0\u10d3\u10d2\u10d4\u10dc\u10d3\u10d0 2 \u10db\u10d8\u10da\u10d8\u10d2\u10e0\u10d0\u10db\u10e1 \u10e1\u10ee\u10d4\u10e3\u10da\u10d8\u10e1 \u10d9\u10d8\u10da\u10dd\u10d2\u10e0\u10d0\u10db\u10d6\u10d4. \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10ef\u10d2\u10e3\u10e4\u10e8\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10d8\u10e7\u10dd 5-\u10d3\u10d0\u10dc 14-\u10db\u10d3\u10d4 \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10d8.<\/p>\n<p>\u10ef\u10d0\u10dc\u10db\u10e0\u10d7\u10d4\u10da \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 AP503-\u10db\u10d0 \u10d2\u10d0\u10d6\u10d0\u10e0\u10d3\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10dd\u10ea\u10e3\u10da\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10e2\u10e0\u10d0\u10d1\u10d4\u10d9\u10e3\u10da\u10e3\u10e0\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e0\u10d0\u10dd\u10d3\u10d4\u10dc\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10e1\u10d8\u10e1\u10e5\u10d4. \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d0\u10e1\u10d4\u10d5\u10d4 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10e1 \u10db\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10da\u10d8\u10e1 \u10d6\u10e0\u10d3\u10d0 \u10d3\u10d0 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d3\u10d0\u10e2\u10d5\u10d8\u10e0\u10d7\u10d5\u10d8\u10e1 \u10db\u10d8\u10db\u10d0\u10e0\u10d7 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e3\u10e4\u10e0\u10dd \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10db\u10d3\u10d2\u10e0\u10d0\u10d3\u10dd\u10d1\u10d0.<\/p>\n<p>\u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8 AP503-\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0\u10db \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d8\u10db\u10d4 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3\u10d8 \u10eb\u10d5\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10d4\u10da\u10d8 \u10d2\u10d0\u10d0\u10e3\u10db\u10ef\u10dd\u10d1\u10d4\u10e1\u10d0 \u10d3\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10d9\u10d0\u10e0\u10d2\u10d5\u10d8\u10e1 \u10dc\u10d8\u10e8\u10dc\u10d4\u10d1\u10d8 \u10e8\u10d4\u10d0\u10db\u10ea\u10d8\u10e0\u10d0. \u10d0\u10d5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d8\u10d7, \u10d4\u10e1 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8 GPR133-\u10e1 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4\u10d3 \u10ec\u10d0\u10e0\u10db\u10dd\u10d0\u10e9\u10d4\u10dc\u10e1.<\/p>\n<p>\u10d0\u10db\u10d0\u10e1\u10d7\u10d0\u10dc, \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10e1 \u10d0\u10e5\u10d5\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10e8\u10d4\u10d6\u10e6\u10e3\u10d3\u10d5\u10d0: \u10db\u10d8\u10e1\u10d8 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10d8 \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10e3\u10e0 \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10d6\u10d4\u10d0 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da\u10d8. \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10e1\u10d0\u10d3\u10d2\u10d4\u10dc\u10d0\u10d3 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10de\u10e0\u10d4\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0, \u10e8\u10d4\u10db\u10d3\u10d4\u10d2 \u10d9\u10d8 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10e1\u10d0\u10d7\u10d0\u10dc\u10d0\u10d3\u10dd\u10d3 \u10d3\u10d0\u10d2\u10d4\u10d2\u10db\u10d8\u10da\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d0\u10db\u10d3\u10d4\u10dc\u10d8\u10db\u10d4 \u10d4\u10e2\u10d0\u10de\u10d8.<\/p>\n<p>\u10ea\u10d0\u10da\u10d9\u10d4 \u10d0\u10e6\u10e1\u10d0\u10dc\u10d8\u10e8\u10dc\u10d0\u10d5\u10d8\u10d0, \u10e0\u10dd\u10db GPR133-\u10d8\u10e1 \u10db\u10d8\u10db\u10d0\u10e0\u10d7 \u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10d8 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10eb\u10d5\u10da\u10d8\u10d7 \u10d0\u10e0 \u10e8\u10d4\u10db\u10dd\u10d8\u10e4\u10d0\u10e0\u10d2\u10da\u10d4\u10d1\u10d0. 2025 \u10ec\u10da\u10d8\u10e1 \u10e1\u10ee\u10d5\u10d0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db \u10d4\u10e1 \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10dd\u10e0\u10d8 \u10d9\u10e3\u10dc\u10d7\u10dd\u10d5\u10d0\u10dc \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10e8\u10d8 \u10d0\u10dc\u10d3\u10e0\u10dd\u10d2\u10d4\u10dc\u10e3\u10da \u10e1\u10d8\u10d2\u10dc\u10d0\u10da\u10d4\u10d1\u10e8\u10d8 \u10db\u10dd\u10dc\u10d0\u10ec\u10d8\u10da\u10d4\u10dd\u10d1\u10e1 \u10d3\u10d0 \u10db\u10d8\u10e1\u10d8 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d0 AP503-\u10d8\u10d7 \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10d9\u10e3\u10dc\u10d7\u10d8\u10e1 \u10eb\u10d0\u10da\u10d8\u10e1 \u10d2\u10d0\u10e3\u10db\u10ef\u10dd\u10d1\u10d4\u10e1\u10d4\u10d1\u10d0\u10e1 \u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d3\u10d4\u10d1\u10dd\u10d3\u10d0.<\/p>\n<p>\u10d0\u10db \u10dd\u10e0\u10d8 \u10db\u10d8\u10db\u10d0\u10e0\u10d7\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d4\u10e0\u10d7\u10d8\u10d0\u10dc\u10d4\u10d1\u10d0\u10db \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd\u10d0 \u10db\u10dd\u10db\u10d0\u10d5\u10d0\u10da\u10e8\u10d8 \u10e1\u10d0\u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10dd \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10da\u10dd\u10d1\u10d4\u10d1\u10d8 \u10e8\u10d4\u10e5\u10db\u10dc\u10d0\u10e1, \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10d0\u10e1\u10d0\u10d9\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d9\u10e3\u10dc\u10d7\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d8\u10e1 \u10d3\u10d0\u10e5\u10d5\u10d4\u10d8\u10d7\u10d4\u10d1\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10e8\u10d8. \u10d7\u10e3\u10db\u10ea\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d0\u10e1\u10d4\u10d7\u10d8 \u10d9\u10dd\u10db\u10d1\u10d8\u10dc\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10e1\u10d0\u10e0\u10d2\u10d4\u10d1\u10d4\u10da\u10d8 \u10ef\u10d4\u10e0 \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<h2>\u10e1\u10d0\u10d4\u10e0\u10d7\u10d0\u10e8\u10dd\u10e0\u10d8\u10e1\u10dd \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d8\u10da\u10d4\u10d1\u10d0<\/h2>\n<p>\u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10d7\u10d0\u10dc\u10d0\u10db\u10d4\u10d3\u10e0\u10dd\u10d5\u10d4 \u10db\u10d0\u10e0\u10d7\u10d5\u10d0 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3\u10d0\u10d3 \u10d4\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10d0 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d8\u10e1 \u10d8\u10dc\u10d3\u10d8\u10d5\u10d8\u10d3\u10e3\u10d0\u10da\u10e3\u10e0\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0\u10e1, \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10d8\u10dc\u10d4\u10e0\u10d0\u10da\u10e3\u10e0\u10d8 \u10e1\u10d8\u10db\u10d9\u10d5\u10e0\u10d8\u10d5\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0\u10e1 \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8, \u10d3\u10d0\u10ea\u10d4\u10db\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1, \u10e4\u10d8\u10d6\u10d8\u10d9\u10e3\u10e0 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10e3\u10e0 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10e1.<\/p>\n<p>\u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10db\u10e1\u10dd\u10e4\u10da\u10d8\u10dd \u10dd\u10e0\u10d2\u10d0\u10dc\u10d8\u10d6\u10d0\u10ea\u10d8\u10d0 \u10d0\u10e6\u10dc\u10d8\u10e8\u10dc\u10d0\u10d5\u10e1, \u10e0\u10dd\u10db \u10d0\u10e1\u10d0\u10d9\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d4\u10d1\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10dc\u10d0\u10ec\u10d8\u10da\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10e7\u10d8\u10e4\u10d4\u10dd\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d0\u10e0\u10d8\u10e1 \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10d0 \u10db\u10d0\u10d7\u10d8 \u10de\u10e0\u10d4\u10d5\u10d4\u10dc\u10ea\u10d8\u10d0 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e3\u10da\u10d8 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d8\u10d7\u10d0 \u10d3\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10d8 \u10db\u10d0\u10e0\u10d7\u10d5\u10d8\u10d7.<\/p>\n<p>\u10d0\u10e8\u10e8-\u10d8\u10e1 \u10d0\u10e0\u10d7\u10e0\u10d8\u10e2\u10d8\u10e1, \u10d9\u10e3\u10dc\u10d7\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d3\u10d0 \u10d9\u10d0\u10dc\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d4\u10e0\u10dd\u10d5\u10dc\u10e3\u10da\u10d8 \u10d8\u10dc\u10e1\u10e2\u10d8\u10e2\u10e3\u10e2\u10d8 \u10ee\u10d0\u10d6\u10e1 \u10e3\u10e1\u10d5\u10d0\u10db\u10e1 \u10ec\u10dd\u10dc\u10d8\u10d7\u10d8 \u10d3\u10d0\u10e2\u10d5\u10d8\u10e0\u10d7\u10d5\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10e4\u10d8\u10d6\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d0\u10e1 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ef\u10d0\u10dc\u10db\u10e0\u10d7\u10d4\u10da\u10dd\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1. \u10d0\u10e1\u10d4\u10d5\u10d4 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10e1\u10d0\u10d9\u10db\u10d0\u10e0\u10d8\u10e1\u10d8 \u10d9\u10d0\u10da\u10ea\u10d8\u10e3\u10db\u10d8\u10e1\u10d0 \u10d3\u10d0 D \u10d5\u10d8\u10e2\u10d0\u10db\u10d8\u10dc\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10d8\u10e1\u10d4\u10d7\u10d8 \u10e0\u10d8\u10e1\u10d9-\u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d8\u10e1 \u10db\u10d0\u10e0\u10d7\u10d5\u10d0, \u10e0\u10dd\u10d2\u10dd\u10e0\u10d8\u10ea\u10d0\u10d0 \u10db\u10dd\u10ec\u10d4\u10d5\u10d0 \u10d3\u10d0 \u10ed\u10d0\u10e0\u10d1\u10d8 \u10d0\u10da\u10d9\u10dd\u10f0\u10dd\u10da\u10d8\u10e1 \u10db\u10dd\u10ee\u10db\u10d0\u10e0\u10d4\u10d1\u10d0.<\/p>\n<p>\u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10e3\u10e0\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d0\u10e0\u10e9\u10d4\u10d5\u10d0 \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d6\u10d4\u10d0 \u10d3\u10d0\u10db\u10dd\u10d9\u10d8\u10d3\u10d4\u10d1\u10e3\u10da\u10d8. \u10d4\u10dc\u10d3\u10dd\u10d9\u10e0\u10d8\u10dc\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10e1\u10d0\u10d6\u10dd\u10d2\u10d0\u10d3\u10dd\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d0\u10ea\u10d8\u10d4\u10d1\u10d8\u10d7, \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10db\u10e5\u10dd\u10dc\u10d4 \u10de\u10dd\u10e1\u10e2\u10db\u10d4\u10dc\u10dd\u10de\u10d0\u10e3\u10d6\u10e3\u10e0 \u10e5\u10d0\u10da\u10d4\u10d1\u10e8\u10d8 \u10d1\u10d8\u10e1\u10e4\u10dd\u10e1\u10e4\u10dd\u10dc\u10d0\u10e2\u10d4\u10d1\u10d8 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da \u10d8\u10e5\u10dc\u10d4\u10e1 \u10e1\u10d0\u10ec\u10e7\u10d8\u10e1 \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0\u10d3, \u10ee\u10dd\u10da\u10dd \u10eb\u10d0\u10da\u10d8\u10d0\u10dc \u10db\u10d0\u10e6\u10d0\u10da\u10d8 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d2\u10d0\u10dc\u10d8\u10ee\u10d8\u10da\u10d4\u10d1\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10e1 \u10db\u10d0\u10e1\u10e2\u10d8\u10db\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d4\u10da\u10d8 \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d4\u10d1\u10d8.<\/p>\n<p>GPR133-\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10d0\u10db \u10e3\u10d9\u10d5\u10d4 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da \u10db\u10d8\u10d3\u10d2\u10dd\u10db\u10d4\u10d1\u10e1 \u10d0\u10e0 \u10ea\u10d5\u10da\u10d8\u10e1. \u10db\u10d8\u10e1\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d1\u10d0 \u10d8\u10db\u10d0\u10e8\u10d8 \u10db\u10d3\u10d2\u10dd\u10db\u10d0\u10e0\u10d4\u10dd\u10d1\u10e1, \u10e0\u10dd\u10db \u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10d8 \u10ea\u10d3\u10d8\u10da\u10dd\u10d1\u10d4\u10dc \u10d8\u10de\u10dd\u10d5\u10dd\u10dc \u10d0\u10ee\u10d0\u10da\u10d8 \u10db\u10dd\u10da\u10d4\u10d9\u10e3\u10da\u10e3\u10e0\u10d8 \u10d2\u10d6\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10e3\u10e8\u10e3\u10d0\u10da\u10dd\u10d3 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e4\u10dd\u10e0\u10db\u10d8\u10e0\u10d4\u10d1\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10e0\u10d4\u10db\u10dd\u10d3\u10d4\u10da\u10d8\u10e0\u10d4\u10d1\u10d0\u10d6\u10d4 \u10d8\u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10e1.<\/p>\n<h2>\u10e1\u10d0\u10e5\u10d0\u10e0\u10d7\u10d5\u10d4\u10da\u10dd\u10e1 \u10d9\u10dd\u10dc\u10e2\u10d4\u10e5\u10e1\u10e2\u10d8<\/h2>\n<p>\u10e1\u10d0\u10e5\u10d0\u10e0\u10d7\u10d5\u10d4\u10da\u10dd\u10e1\u10d7\u10d5\u10d8\u10e1 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10e1\u10d0\u10d9\u10d8\u10d7\u10ee\u10d8 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10db\u10dd\u10e1\u10d0\u10ee\u10da\u10d4\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d1\u10d4\u10e0\u10d4\u10d1\u10d8\u10e1, \u10e4\u10d8\u10d6\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d8\u10e1, \u10d9\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d7\u10d0\u10d5\u10d8\u10e1\u10d4\u10d1\u10e3\u10e0\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e5\u10e0\u10dd\u10dc\u10d8\u10d9\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d8\u10e1 \u10d9\u10dd\u10dc\u10e2\u10d4\u10e5\u10e1\u10e2\u10e8\u10d8. \u10d0\u10e1\u10d0\u10d9\u10d8\u10e1 \u10db\u10d0\u10e2\u10d4\u10d1\u10d0\u10e1\u10d7\u10d0\u10dc \u10d4\u10e0\u10d7\u10d0\u10d3 \u10d8\u10d6\u10e0\u10d3\u10d4\u10d1\u10d0 \u10e0\u10dd\u10d2\u10dd\u10e0\u10ea \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10d9\u10d0\u10e0\u10d2\u10d5\u10d8\u10e1, \u10d8\u10e1\u10d4 \u10d3\u10d0\u10ea\u10d4\u10db\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8.<\/p>\n<p>\u10de\u10e0\u10d0\u10e5\u10e2\u10d8\u10d9\u10e3\u10da\u10d8 \u10d7\u10d5\u10d0\u10da\u10e1\u10d0\u10d6\u10e0\u10d8\u10e1\u10d8\u10d7, \u10d0\u10ee\u10d0\u10da\u10d8 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10dc\u10d0\u10d4\u10e0\u10d7\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10d8\u10dc\u10e4\u10dd\u10e0\u10db\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d2\u10d0\u10d5\u10e0\u10ea\u10d4\u10da\u10d4\u10d1\u10d8\u10e1\u10d0\u10e1 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0 \u10db\u10d9\u10d0\u10e4\u10d8\u10dd \u10d2\u10d0\u10dc\u10e1\u10ee\u10d5\u10d0\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10d9\u10d4\u10d7\u10d4\u10d1\u10d0 \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d0\u10d3 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10e1 \u10e8\u10dd\u10e0\u10d8\u10e1.<\/p>\n<p>AP503 \u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10e1\u10e2\u10d0\u10dc\u10d3\u10d0\u10e0\u10e2\u10e3\u10da\u10d8 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d0. \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d0\u10d3, \u10de\u10d0\u10ea\u10d8\u10d4\u10dc\u10e2\u10d4\u10d1\u10db\u10d0 \u10d0\u10e0 \u10e3\u10dc\u10d3\u10d0 \u10e8\u10d4\u10d8\u10eb\u10d8\u10dc\u10dd\u10dc \u10d0\u10dc \u10d2\u10d0\u10db\u10dd\u10d8\u10e7\u10d4\u10dc\u10dd\u10dc \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d8 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10dc\u10d0\u10d4\u10e0\u10d7\u10d4\u10d1\u10d8 \u10d4\u10e5\u10d8\u10db\u10d8\u10e1 \u10d3\u10d0\u10dc\u10d8\u10e8\u10dc\u10e3\u10da\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10e0\u10d4\u10e8\u10d4. \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10dc\u10d8\u10d5\u10d7\u10d8\u10d4\u10e0\u10d4\u10d1\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da \u10d7\u10d4\u10e0\u10d0\u10de\u10d8\u10d0\u10d3 \u10d0\u10e0 \u10e3\u10dc\u10d3\u10d0 \u10e9\u10d0\u10d8\u10d7\u10d5\u10d0\u10da\u10dd\u10e1.<\/p>\n<p>\u10e5\u10d0\u10e0\u10d7\u10e3\u10da\u10d8 \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10d8\u10dc\u10e4\u10dd\u10e0\u10db\u10d0\u10ea\u10d8\u10d8\u10e1 \u10ee\u10d0\u10e0\u10d8\u10e1\u10ee\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0, \u10e0\u10dd\u10db \u10d0\u10e1\u10d4\u10d7\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d3\u10d4\u10e1 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8\u10e1 \u10d8\u10d4\u10e0\u10d0\u10e0\u10e5\u10d8\u10d8\u10e1 \u10d2\u10d0\u10d7\u10d5\u10d0\u10da\u10d8\u10e1\u10ec\u10d8\u10dc\u10d4\u10d1\u10d8\u10d7. \u10d0\u10d9\u10d0\u10d3\u10d4\u10db\u10d8\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d0\u10d7\u10d8 \u10db\u10d4\u10d7\u10dd\u10d3\u10dd\u10da\u10dd\u10d2\u10d8\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10d3\u10d0\u10db\u10d0\u10e2\u10d4\u10d1\u10d8\u10d7\u10d8 \u10d8\u10dc\u10e4\u10dd\u10e0\u10db\u10d0\u10ea\u10d8\u10d0 \u10db\u10d9\u10d8\u10d7\u10ee\u10d5\u10d4\u10da\u10e1 \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0 \u10d2\u10d0\u10d4\u10ea\u10dc\u10dd\u10e1 <a href=\"https:\/\/www.gmj.ge\/?utm_source=chatgpt.com\">\u10e1\u10d0\u10e5\u10d0\u10e0\u10d7\u10d5\u10d4\u10da\u10dd\u10e1 \u10e1\u10d0\u10db\u10d4\u10d3\u10d8\u10ea\u10d8\u10dc\u10dd \u10df\u10e3\u10e0\u10dc\u10d0\u10da\u10d8\u10e1 \u10d0\u10d9\u10d0\u10d3\u10d4\u10db\u10d8\u10e3\u10e0 \u10e1\u10d8\u10d5\u10e0\u10ea\u10d4\u10e8\u10d8<\/a>, \u10ee\u10dd\u10da\u10dd \u10ee\u10d0\u10e0\u10d8\u10e1\u10ee\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10e1\u10e2\u10d0\u10dc\u10d3\u10d0\u10e0\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d9\u10d8\u10d7\u10ee\u10d4\u10d1\u10d6\u10d4 \u2014 <a href=\"https:\/\/www.certificate.ge\/?utm_source=chatgpt.com\">certificate.ge-\u10d8\u10e1 \u10e0\u10d4\u10e1\u10e3\u10e0\u10e1\u10d4\u10d1\u10e8\u10d8<\/a>.<\/p>\n<p>\u10e1\u10d0\u10d6\u10dd\u10d2\u10d0\u10d3\u10dd\u10d4\u10d1\u10e0\u10d8\u10d5\u10d8 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10d7\u10d5\u10d0\u10da\u10e1\u10d0\u10d6\u10e0\u10d8\u10e1\u10d8\u10d7, \u10db\u10e1\u10d2\u10d0\u10d5\u10e1\u10d8 \u10d0\u10ee\u10d0\u10da\u10d8 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10de\u10d0\u10e0\u10d0\u10da\u10d4\u10da\u10e3\u10e0\u10d0\u10d3 \u10d9\u10d5\u10da\u10d0\u10d5 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e3\u10da\u10d8 \u10d2\u10d0\u10db\u10dd\u10d5\u10da\u10d4\u10dc\u10d0, \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0, \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd \u10e4\u10d8\u10d6\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d0 \u10d3\u10d0 \u10d4\u10e5\u10d8\u10db\u10d7\u10d0\u10dc \u10d8\u10dc\u10d3\u10d8\u10d5\u10d8\u10d3\u10e3\u10d0\u10da\u10e3\u10e0\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10d2\u10d4\u10d2\u10db\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d6\u10e6\u10d5\u10e0\u10d0. \u10ef\u10d0\u10dc\u10db\u10e0\u10d7\u10d4\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10ee\u10d4\u10d1 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d6\u10d4 \u10d3\u10d0\u10e4\u10e3\u10eb\u10dc\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10d0\u10e1\u10d0\u10da\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10db\u10d0\u10e2\u10d4\u10d1\u10d8\u10d7\u10d8 \u10e0\u10d4\u10e1\u10e3\u10e0\u10e1\u10d4\u10d1\u10d8 \u10ee\u10d4\u10da\u10db\u10d8\u10e1\u10d0\u10ec\u10d5\u10d3\u10dd\u10db\u10d8\u10d0 <a href=\"https:\/\/www.sheniekimi.ge\/?utm_source=chatgpt.com\">SheniEkimi.ge-\u10d6\u10d4<\/a> \u10d3\u10d0 <a href=\"https:\/\/www.publichealth.ge\/?utm_source=chatgpt.com\">\u10e1\u10d0\u10d6\u10dd\u10d2\u10d0\u10d3\u10dd\u10d4\u10d1\u10e0\u10d8\u10d5\u10d8 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10e1\u10d0\u10d2\u10d0\u10dc\u10db\u10d0\u10dc\u10d0\u10d7\u10da\u10d4\u10d1\u10da\u10dd \u10e1\u10d8\u10d5\u10e0\u10ea\u10d4\u10e8\u10d8<\/a>.<\/p>\n<h2>\u10db\u10d8\u10d7\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0<\/h2>\n<p><strong>\u10db\u10d8\u10d7\u10d8: AP503 \u10e3\u10d9\u10d5\u10d4 \u10d0\u10ee\u10d0\u10da\u10d8 \u10ec\u10d0\u10db\u10d0\u10da\u10d8\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3.<\/strong><\/p>\n<p>\u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0: AP503 \u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10dc\u10d0\u10d4\u10e0\u10d7\u10d8\u10d0. \u10db\u10d8\u10e1\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e5\u10e1\u10dd\u10d5\u10d8\u10da\u10d6\u10d4 \u10eb\u10d8\u10e0\u10d8\u10d7\u10d0\u10d3\u10d0\u10d3 \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8\u10d0 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10da\u10d8 \u10d3\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d0 \u10ef\u10d4\u10e0 \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p><strong>\u10db\u10d8\u10d7\u10d8: \u10d7\u10e3 \u10dc\u10d0\u10d4\u10e0\u10d7\u10db\u10d0 \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e1\u10d8\u10db\u10e2\u10d9\u10d8\u10ea\u10d4 \u10d2\u10d0\u10d6\u10d0\u10e0\u10d3\u10d0, \u10d8\u10d2\u10d8\u10d5\u10d4 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10da\u10d0\u10d3 \u10d4\u10e5\u10dc\u10d4\u10d1\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10e1.<\/strong><\/p>\n<p>\u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0: \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10e3\u10e0 \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10e8\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10d0\u10ee\u10d0\u10da\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10e5\u10db\u10dc\u10d4\u10da\u10d0\u10d3, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10db\u10d0\u10d7\u10d8 \u10d2\u10d0\u10db\u10d4\u10dd\u10e0\u10d4\u10d1\u10d0 \u10d0\u10d5\u10e2\u10dd\u10db\u10d0\u10e2\u10e3\u10e0\u10d0\u10d3 \u10d2\u10d0\u10e0\u10d0\u10dc\u10e2\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d0\u10e0 \u10d0\u10e0\u10d8\u10e1.<\/p>\n<p><strong>\u10db\u10d8\u10d7\u10d8: \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1 \u10e1\u10d0\u10d9\u10db\u10d0\u10e0\u10d8\u10e1\u10d8\u10d0 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10d9\u10d0\u10da\u10ea\u10d8\u10e3\u10db\u10d8\u10e1 \u10db\u10d8\u10e6\u10d4\u10d1\u10d0.<\/strong><\/p>\n<p>\u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0: \u10eb\u10d5\u10da\u10d8\u10e1 \u10ef\u10d0\u10dc\u10db\u10e0\u10d7\u10d4\u10da\u10dd\u10d1\u10d0\u10d6\u10d4 \u10db\u10e0\u10d0\u10d5\u10d0\u10da\u10d8 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d8 \u10db\u10dd\u10e5\u10db\u10d4\u10d3\u10d4\u10d1\u10e1. \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d0\u10e0\u10e1\u10d4\u10d1\u10dd\u10d1\u10d8\u10e1\u10d0\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10d9\u10dd\u10dc\u10d9\u10e0\u10d4\u10e2\u10e3\u10da\u10d8 \u10de\u10e0\u10d4\u10de\u10d0\u10e0\u10d0\u10e2\u10d8\u10e1 \u10d0\u10e0\u10e9\u10d4\u10d5\u10d0 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d6\u10d4, \u10eb\u10d5\u10da\u10d8\u10e1 \u10e1\u10d8\u10db\u10d9\u10d5\u10e0\u10d8\u10d5\u10d4\u10d6\u10d4, \u10d0\u10e1\u10d0\u10d9\u10d6\u10d4 \u10d3\u10d0 \u10e1\u10ee\u10d5\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0 \u10e4\u10d0\u10e5\u10e2\u10dd\u10e0\u10d4\u10d1\u10d6\u10d4\u10d0 \u10d3\u10d0\u10db\u10dd\u10d9\u10d8\u10d3\u10d4\u10d1\u10e3\u10da\u10d8.<\/p>\n<p><strong>\u10db\u10d8\u10d7\u10d8: \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8 \u10db\u10ee\u10dd\u10da\u10dd\u10d3 \u10e5\u10d0\u10da\u10d4\u10d1\u10d8\u10e1 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10d0.<\/strong><\/p>\n<p>\u10e0\u10d4\u10d0\u10da\u10dd\u10d1\u10d0: \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8 \u10e5\u10d0\u10da\u10d4\u10d1\u10e8\u10d8, \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10db\u10d4\u10dc\u10dd\u10de\u10d0\u10e3\u10d6\u10d8\u10e1 \u10e8\u10d4\u10db\u10d3\u10d4\u10d2, \u10db\u10d0\u10e6\u10d0\u10da\u10d8\u10d0, \u10db\u10d0\u10d2\u10e0\u10d0\u10db \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8 \u10db\u10d0\u10db\u10d0\u10d9\u10d0\u10ea\u10d4\u10d1\u10e1\u10d0\u10ea \u10d4\u10db\u10d0\u10e0\u10d7\u10d4\u10d1\u10d0\u10d7.<\/p>\n<h2>\u10ee\u10e8\u10d8\u10e0\u10d0\u10d3 \u10d3\u10d0\u10e1\u10db\u10e3\u10da\u10d8 \u10d9\u10d8\u10d7\u10ee\u10d5\u10d4\u10d1\u10d8 (Q&amp;A)<\/h2>\n<p><strong>\u10e0\u10d0 \u10d0\u10e0\u10d8\u10e1 GPR133?<\/strong><\/p>\n<p>GPR133, \u10d8\u10d2\u10d8\u10d5\u10d4 ADGRD1, \u10d0\u10e0\u10d8\u10e1 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d8\u10e1 \u10db\u10d4\u10db\u10d1\u10e0\u10d0\u10dc\u10d0\u10d6\u10d4 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10e0\u10d4\u10ea\u10d4\u10de\u10e2\u10dd\u10e0\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10db\u10dd\u10dc\u10d0\u10ec\u10d8\u10da\u10d4\u10dd\u10d1\u10e1 \u10e1\u10ee\u10d5\u10d0\u10d3\u10d0\u10e1\u10ee\u10d5\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10e3\u10da \u10e1\u10d0\u10e1\u10d8\u10d2\u10dc\u10d0\u10da\u10dd \u10de\u10e0\u10dd\u10ea\u10d4\u10e1\u10e8\u10d8. \u10d0\u10ee\u10d0\u10da\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8 \u10db\u10d8\u10e3\u10d7\u10d8\u10d7\u10d4\u10d1\u10e1 \u10db\u10d8\u10e1 \u10e0\u10dd\u10da\u10d6\u10d4 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10db\u10e5\u10db\u10dc\u10d4\u10da\u10d8 \u10e3\u10ef\u10e0\u10d4\u10d3\u10d4\u10d1\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d0\u10e1\u10d0 \u10d3\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e0\u10d4\u10db\u10dd\u10d3\u10d4\u10da\u10d8\u10e0\u10d4\u10d1\u10d0\u10e8\u10d8.<\/p>\n<p><strong>\u10e0\u10d0 \u10d0\u10e0\u10d8\u10e1 AP503?<\/strong><\/p>\n<p>AP503 \u10d0\u10e0\u10d8\u10e1 \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10db\u10ea\u10d8\u10e0\u10d4 \u10db\u10dd\u10da\u10d4\u10d9\u10e3\u10da\u10d0, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea GPR133-\u10d8\u10e1 \u10d0\u10e5\u10e2\u10d8\u10d5\u10d0\u10ea\u10d8\u10d0\u10e1 \u10d8\u10ec\u10d5\u10d4\u10d5\u10e1. \u10db\u10d8\u10e1\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d4\u10d1\u10d8 \u10eb\u10d5\u10d0\u10da\u10e1\u10d0 \u10d3\u10d0 \u10d9\u10e3\u10dc\u10d7\u10d6\u10d4 \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10e3\u10e0 \u10db\u10dd\u10d3\u10d4\u10da\u10d4\u10d1\u10e8\u10d8\u10d0 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10da\u10d8.<\/p>\n<p><strong>\u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10d7\u10e3 \u10d0\u10e0\u10d0 \u10db\u10d8\u10e1\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8?<\/strong><\/p>\n<p>\u10d0\u10e0\u10d0. \u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10d0\u10e0\u10e1\u10d4\u10d1\u10e3\u10da\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10db\u10dd\u10dc\u10d0\u10ea\u10d4\u10db\u10d4\u10d1\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da\u10d8\u10d0 \u10e3\u10ef\u10e0\u10d4\u10d3\u10e3\u10da \u10d3\u10d0 \u10ea\u10ee\u10dd\u10d5\u10d4\u10da\u10e3\u10e0 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10e8\u10d8. \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d8\u10e1 \u10d3\u10d0\u10e1\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10da\u10d0\u10d3 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8.<\/p>\n<p><strong>\u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10d7\u10e3 \u10d0\u10e0\u10d0 AP503-\u10d8\u10e1 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3?<\/strong><\/p>\n<p>\u10d0\u10db \u10d4\u10e2\u10d0\u10de\u10d6\u10d4 \u10d7\u10d5\u10d8\u10d7\u10dc\u10d4\u10d1\u10e3\u10e0\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d0 \u10d3\u10d0\u10e3\u10e8\u10d5\u10d4\u10d1\u10d4\u10da\u10d8\u10d0. \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10d7\u10d8 \u10dc\u10d0\u10d4\u10e0\u10d7\u10d8 \u10d0\u10e0 \u10e3\u10dc\u10d3\u10d0 \u10e9\u10d0\u10d8\u10d7\u10d5\u10d0\u10da\u10dd\u10e1 \u10d3\u10d0\u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10e8\u10e3\u10d0\u10da\u10d4\u10d1\u10d0\u10d3.<\/p>\n<p><strong>\u10e0\u10d0\u10e2\u10dd\u10db \u10d0\u10e0\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8?<\/strong><\/p>\n<p>\u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10e1, \u10e0\u10dd\u10db GPR133 \u10e8\u10d4\u10d8\u10eb\u10da\u10d4\u10d1\u10d0 \u10db\u10dd\u10dc\u10d0\u10ec\u10d8\u10da\u10d4\u10dd\u10d1\u10d3\u10d4\u10e1 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10e1 \u10e0\u10d4\u10d2\u10e3\u10da\u10d8\u10e0\u10d4\u10d1\u10d0\u10e8\u10d8 \u10d3\u10d0 \u10db\u10dd\u10db\u10d0\u10d5\u10d0\u10da\u10e8\u10d8 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd\u10d0 \u10d2\u10d0\u10ee\u10d3\u10d4\u10e1 \u10d0\u10ee\u10d0\u10da\u10d8 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d4. \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10e1\u10d0\u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10dd\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d8\u10e1 \u10d2\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d4\u10d1\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10e8\u10da\u10d8\u10e1 \u10e8\u10d4\u10db\u10ea\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10d4\u10e0\u10d7\u10d3\u10e0\u10dd\u10e3\u10da\u10d8 \u10d4\u10e4\u10d4\u10e5\u10e2\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10da\u10dd\u10d1\u10d0.<\/p>\n<p><strong>\u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10d7\u10e3 \u10d0\u10e0\u10d0 GPR133 \u10d9\u10e3\u10dc\u10d7\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d0\u10e1\u10d0\u10ea?<\/strong><\/p>\n<p>\u10d3\u10d8\u10d0\u10ee. \u10ea\u10d0\u10da\u10d9\u10d4, 2025 \u10ec\u10da\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0\u10db \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db GPR133-\u10d8\u10e1 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d0 AP503-\u10d8\u10d7 \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10d9\u10e3\u10dc\u10d7\u10d8\u10e1 \u10eb\u10d0\u10da\u10d8\u10e1 \u10d2\u10d0\u10e3\u10db\u10ef\u10dd\u10d1\u10d4\u10e1\u10d4\u10d1\u10d0\u10e1 \u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d3\u10d4\u10d1\u10dd\u10d3\u10d0. \u10d7\u10e3\u10db\u10ea\u10d0 \u10d4\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8\u10ea \u10ef\u10d4\u10e0 \u10d0\u10e0 \u10dc\u10d8\u10e8\u10dc\u10d0\u10d5\u10e1 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d3\u10d0\u10d3\u10d0\u10e1\u10e2\u10e3\u10e0\u10d4\u10d1\u10e3\u10da \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0\u10e1.<\/p>\n<h2>\u10d3\u10d0\u10e1\u10d9\u10d5\u10dc\u10d0 \u2014 \u10e1\u10d0\u10d6\u10dd\u10d2\u10d0\u10d3\u10dd\u10d4\u10d1\u10e0\u10d8\u10d5\u10d8 \u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10de\u10d4\u10e0\u10e1\u10de\u10d4\u10e5\u10e2\u10d8\u10d5\u10d8\u10d7<\/h2>\n<p>GPR133-\u10d8\u10e1\u10d0 \u10d3\u10d0 AP503-\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd \u10d0\u10ee\u10d0\u10da\u10d8 \u10d1\u10d8\u10dd\u10da\u10dd\u10d2\u10d8\u10e3\u10e0\u10d8 \u10e1\u10d0\u10db\u10d8\u10d6\u10dc\u10d8\u10e1 \u10eb\u10d8\u10d4\u10d1\u10d8\u10e1 \u10e1\u10d0\u10d8\u10dc\u10e2\u10d4\u10e0\u10d4\u10e1\u10dd \u10db\u10d0\u10d2\u10d0\u10da\u10d8\u10d7\u10d8\u10d0. \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da\u10db\u10d0 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10db\u10d0 \u10d0\u10e9\u10d5\u10d4\u10dc\u10d0, \u10e0\u10dd\u10db GPR133-\u10d8\u10e1 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d0\u10e1 \u10e8\u10d4\u10e3\u10eb\u10da\u10d8\u10d0 \u10d2\u10d0\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10dd\u10e1 \u10dd\u10e1\u10e2\u10d4\u10dd\u10d1\u10da\u10d0\u10e1\u10e2\u10d4\u10d1\u10d8\u10e1 \u10e4\u10e3\u10dc\u10e5\u10ea\u10d8\u10d0, \u10d2\u10d0\u10d6\u10d0\u10e0\u10d3\u10dd\u10e1 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0, \u10e8\u10d4\u10d0\u10db\u10ea\u10d8\u10e0\u10dd\u10e1 \u10d6\u10dd\u10d2\u10d8\u10d4\u10e0\u10d7\u10d8 \u10db\u10d0\u10e9\u10d5\u10d4\u10dc\u10d4\u10d1\u10d4\u10da\u10d8, \u10e0\u10dd\u10db\u10d4\u10da\u10d8\u10ea \u10eb\u10d5\u10da\u10d8\u10e1 \u10d3\u10d0\u10e8\u10da\u10d0\u10e1 \u10e3\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0, \u10d3\u10d0 \u10d2\u10d0\u10d0\u10e3\u10db\u10ef\u10dd\u10d1\u10d4\u10e1\u10dd\u10e1 \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10d4\u10e5\u10d0\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10db\u10d3\u10d2\u10e0\u10d0\u10d3\u10dd\u10d1\u10d0. \u10d4\u10e5\u10e1\u10de\u10d4\u10e0\u10d8\u10db\u10d4\u10dc\u10e2\u10e3\u10da\u10d8 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10db\u10dd\u10d3\u10d4\u10da\u10e8\u10d8\u10ea \u10d3\u10d0\u10e4\u10d8\u10e5\u10e1\u10d8\u10e0\u10d3\u10d0 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d2\u10d0\u10e3\u10db\u10ef\u10dd\u10d1\u10d4\u10e1\u10d4\u10d1\u10d0.<\/p>\n<p>\u10d0\u10db\u10d0\u10d5\u10d4 \u10d3\u10e0\u10dd\u10e1, \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10e1\u10d8\u10e4\u10e0\u10d7\u10ee\u10d8\u10da\u10d4 \u10d0\u10e3\u10ea\u10d8\u10da\u10d4\u10d1\u10d4\u10da\u10d8\u10d0. \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10db\u10d8\u10e6\u10d4\u10d1\u10e3\u10da\u10d8 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d8 \u10ef\u10d4\u10e0 \u10d5\u10d4\u10e0 \u10d2\u10d0\u10ee\u10d3\u10d4\u10d1\u10d0 \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10d8\u10e1\u10d7\u10d5\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d4\u10d9\u10dd\u10db\u10d4\u10dc\u10d3\u10d0\u10ea\u10d8\u10d8\u10e1 \u10e1\u10d0\u10e4\u10e3\u10eb\u10d5\u10d4\u10da\u10d8. \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d0 \u10d3\u10d0\u10db\u10d0\u10e2\u10d4\u10d1\u10d8\u10d7\u10d8 \u10ec\u10d8\u10dc\u10d0\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10d5\u10da\u10d4\u10d5\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e8\u10d4\u10db\u10d3\u10d2\u10dd\u10db \u10d0\u10d3\u10d0\u10db\u10d8\u10d0\u10dc\u10d4\u10d1\u10e8\u10d8 \u10d9\u10d0\u10e0\u10d2\u10d0\u10d3 \u10d3\u10d0\u10d2\u10d4\u10d2\u10db\u10d8\u10da\u10d8 \u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d2\u10d0\u10db\u10dd\u10ea\u10d3\u10d4\u10d1\u10d8, \u10e0\u10d0\u10d7\u10d0 \u10d3\u10d0\u10d3\u10d2\u10d8\u10dc\u10d3\u10d4\u10e1 AP503-\u10d8\u10e1 \u10d4\u10e4\u10d4\u10e5\u10e2\u10e3\u10e0\u10dd\u10d1\u10d0, \u10e3\u10e1\u10d0\u10e4\u10e0\u10d7\u10ee\u10dd\u10d4\u10d1\u10d0, \u10d3\u10dd\u10d6\u10d8\u10e0\u10d4\u10d1\u10d0, \u10ee\u10d0\u10dc\u10d2\u10e0\u10eb\u10da\u10d8\u10d5\u10d8 \u10d2\u10d0\u10db\u10dd\u10e7\u10d4\u10dc\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10d3\u10d4\u10d2\u10d4\u10d1\u10d8 \u10d3\u10d0 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10dd \u10d2\u10d5\u10d4\u10e0\u10d3\u10d8\u10d7\u10d8 \u10db\u10dd\u10d5\u10da\u10d4\u10dc\u10d4\u10d1\u10d8.<\/p>\n<p>\u10e1\u10d0\u10dc\u10d0\u10db \u10d0\u10e1\u10d4\u10d7\u10d8 \u10db\u10e2\u10d9\u10d8\u10ea\u10d4\u10d1\u10e3\u10da\u10d4\u10d1\u10d4\u10d1\u10d8 \u10d3\u10d0\u10d2\u10e0\u10dd\u10d5\u10d3\u10d4\u10d1\u10d0, \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10de\u10e0\u10d4\u10d5\u10d4\u10dc\u10ea\u10d8\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d0\u10e0\u10d7\u10d5\u10d8\u10e1 \u10e1\u10d0\u10e4\u10e3\u10eb\u10d5\u10da\u10d0\u10d3 \u10e0\u10e9\u10d4\u10d1\u10d0 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8\u10e1 \u10e8\u10d4\u10e4\u10d0\u10e1\u10d4\u10d1\u10d0, \u10e8\u10d4\u10e1\u10d0\u10d1\u10d0\u10db\u10d8\u10e1\u10d8 \u10e4\u10d8\u10d6\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d0\u10e5\u10e2\u10d8\u10d5\u10dd\u10d1\u10d0, \u10d9\u10d5\u10d4\u10d1\u10d8\u10e1 \u10d0\u10d3\u10d4\u10d9\u10d5\u10d0\u10e2\u10e3\u10e0\u10d8 \u10e0\u10d4\u10df\u10d8\u10db\u10d8, \u10d3\u10d0\u10ea\u10d4\u10db\u10d8\u10e1 \u10de\u10e0\u10d4\u10d5\u10d4\u10dc\u10ea\u10d8\u10d0 \u10d3\u10d0 \u10e1\u10d0\u10ed\u10d8\u10e0\u10dd\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10db\u10d7\u10ee\u10d5\u10d4\u10d5\u10d0\u10e8\u10d8 \u10d4\u10e5\u10d8\u10db\u10d8\u10e1 \u10db\u10d8\u10d4\u10e0 \u10e8\u10d4\u10e0\u10e9\u10d4\u10e3\u10da\u10d8 \u10db\u10d4\u10d3\u10d8\u10d9\u10d0\u10db\u10d4\u10dc\u10e2\u10e3\u10e0\u10d8 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0.<\/p>\n<p>\u10d0\u10ee\u10d0\u10da\u10d8 \u10d0\u10e6\u10db\u10dd\u10e9\u10d4\u10dc\u10d4\u10d1\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10d0\u10e0\u10d0 \u10d8\u10db\u10d8\u10e2\u10dd\u10db, \u10e0\u10dd\u10db \u10e3\u10d9\u10d5\u10d4 \u10e8\u10d4\u10ea\u10d5\u10d0\u10da\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d1\u10d0, \u10d0\u10e0\u10d0\u10db\u10d4\u10d3 \u10d8\u10db\u10d8\u10e2\u10dd\u10db, \u10e0\u10dd\u10db \u10d8\u10e1\u10d8\u10dc\u10d8 \u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10d4\u10d1\u10e1 \u10eb\u10d5\u10da\u10d8\u10e1 \u10e0\u10d4\u10db\u10dd\u10d3\u10d4\u10da\u10d8\u10e0\u10d4\u10d1\u10d8\u10e1 \u10e3\u10e4\u10e0\u10dd \u10d6\u10e3\u10e1\u10e2\u10d0\u10d3 \u10db\u10d0\u10e0\u10d7\u10d5\u10d8\u10e1 \u10d0\u10ee\u10d0\u10da\u10d8 \u10d2\u10d6\u10d4\u10d1\u10d8\u10e1 \u10e8\u10d4\u10e1\u10ec\u10d0\u10d5\u10da\u10d8\u10e1 \u10e8\u10d4\u10e1\u10d0\u10eb\u10da\u10d4\u10d1\u10da\u10dd\u10d1\u10d0\u10e1 \u10d0\u10eb\u10da\u10d4\u10d5\u10e1.<\/p>\n<h2>\u10ec\u10e7\u10d0\u10e0\u10dd\u10d4\u10d1\u10d8<\/h2>\n<ol>\n<li>Lehmann J, Lin H, Zhang Z, et al. The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133\/ADGRD1) enhances bone formation. <em>Signal Transduction and Targeted Therapy<\/em>. 2025;10:199. <a href=\"https:\/\/www.nature.com\/articles\/s41392-025-02291-y?utm_source=chatgpt.com\">\u10e1\u10e2\u10d0\u10e2\u10d8\u10d8\u10e1 \u10e1\u10e0\u10e3\u10da\u10d8 \u10e2\u10d4\u10e5\u10e1\u10e2\u10d8<\/a><\/li>\n<li>Yang Z, Ping YQ, Wang MW, et al. Identification, structure, and agonist design of an androgen membrane receptor. <em>Cell<\/em>. 2025;188(6):1589-1604.e24. <a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0092867425000352?utm_source=chatgpt.com\">\u10e1\u10e2\u10d0\u10e2\u10d8\u10d8\u10e1 \u10e1\u10e0\u10e3\u10da\u10d8 \u10e2\u10d4\u10e5\u10e1\u10e2\u10d8<\/a><\/li>\n<li>National Institute of Arthritis and Musculoskeletal and Skin Diseases. What Is Bone? <a href=\"https:\/\/www.niams.nih.gov\/health-topics\/what-bone?utm_source=chatgpt.com\">NIAMS-\u10d8\u10e1 \u10e1\u10d0\u10db\u10d4\u10ea\u10dc\u10d8\u10d4\u10e0\u10dd \u10e0\u10d4\u10e1\u10e3\u10e0\u10e1\u10d8<\/a><\/li>\n<li>National Institute of Arthritis and Musculoskeletal and Skin Diseases. Osteoporosis: Diagnosis, Treatment, and Steps to Take. <a href=\"https:\/\/www.niams.nih.gov\/health-topics\/osteoporosis\/basics\/diagnosis-treatment-and-steps-to-take?utm_source=chatgpt.com\">NIAMS-\u10d8\u10e1 \u10e0\u10d4\u10e1\u10e3\u10e0\u10e1\u10d8 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d6\u10d4<\/a><\/li>\n<li>World Health Organization. Fragility fractures. 25 September 2024. <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/fragility-fractures?utm_source=chatgpt.com\">\u10ef\u10d0\u10dc\u10d3\u10d0\u10ea\u10d5\u10d8\u10e1 \u10db\u10e1\u10dd\u10e4\u10da\u10d8\u10dd \u10dd\u10e0\u10d2\u10d0\u10dc\u10d8\u10d6\u10d0\u10ea\u10d8\u10d8\u10e1 \u10d0\u10dc\u10d2\u10d0\u10e0\u10d8\u10e8\u10d8<\/a><\/li>\n<li>Endocrine Society. Pharmacological Management of Osteoporosis in Postmenopausal Women. <a href=\"https:\/\/www.endocrine.org\/clinical-practice-guidelines\/osteoporosis-in-postmenopausal-women?utm_source=chatgpt.com\">\u10d9\u10da\u10d8\u10dc\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d2\u10d0\u10d8\u10d3\u10da\u10d0\u10d8\u10dc\u10d8<\/a><\/li>\n<li>Universit\u00e4t Leipzig. Research for stronger bones and muscles in old age. 2025. <a href=\"https:\/\/research.uni-leipzig.de\/sfb1423\/research-for-stronger-bones-and-muscles-in-old-age\/?utm_source=chatgpt.com\">\u10da\u10d0\u10d8\u10e4\u10ea\u10d8\u10d2\u10d8\u10e1 \u10e3\u10dc\u10d8\u10d5\u10d4\u10e0\u10e1\u10d8\u10e2\u10d4\u10e2\u10d8\u10e1 \u10d9\u10d5\u10da\u10d4\u10d5\u10d8\u10e1 \u10db\u10d8\u10db\u10dd\u10ee\u10d8\u10da\u10d5\u10d0<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>GPR133-\u10d8\u10e1 \u10d2\u10d0\u10d0\u10e5\u10e2\u10d8\u10e3\u10e0\u10d4\u10d1\u10d0\u10db \u10d7\u10d0\u10d2\u10d5\u10d4\u10d1\u10e8\u10d8 \u10eb\u10d5\u10da\u10d8\u10e1 \u10ec\u10d0\u10e0\u10db\u10dd\u10e5\u10db\u10dc\u10d0 \u10d2\u10d0\u10d0\u10eb\u10da\u10d8\u10d4\u10e0\u10d0 \u2014 \u10d0\u10ee\u10d0\u10da\u10d8 \u10db\u10d8\u10d3\u10d2\u10dd\u10db\u10d0 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8\u10e1 \u10e1\u10d0\u10db\u10d9\u10e3\u10e0\u10dc\u10d0\u10da\u10dd\u10d3 \u10e8\u10d4\u10e1\u10d0\u10d5\u10d0\u10da\u10d8 \u2014 \u10d0\u10dc\u10d0\u10da\u10d8\u10e2\u10d8\u10d9\u10e3\u10e0\u10d8 \u10d9\u10dd\u10db\u10d4\u10dc\u10e2\u10d0\u10e0\u10d8 \u10dd\u10e1\u10e2\u10d4\u10dd\u10de\u10dd\u10e0\u10dd\u10d6\u10d8 \u10d4\u10e0\u10d7-\u10d4\u10e0\u10d7\u10d8 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8 \u10d0\u10e1\u10d0\u10d9\u10d7\u10d0\u10dc \u10d3\u10d0\u10d9\u10d0\u10d5\u10e8\u10d8\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d0\u10d0, \u10e0\u10dd\u10db\u10da\u10d8\u10e1 \u10d3\u10e0\u10dd\u10e1\u10d0\u10ea \u10eb\u10d5\u10da\u10d8\u10e1 \u10e1\u10d8\u10db\u10d9\u10d5\u10e0\u10d8\u10d5\u10d4 \u10d3\u10d0 \u10e1\u10d8\u10db\u10e2\u10d9\u10d8\u10ea\u10d4 \u10db\u10ea\u10d8\u10e0\u10d3\u10d4\u10d1\u10d0 \u10d3\u10d0 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d8\u10e1 \u10e0\u10d8\u10e1\u10d9\u10d8 \u10d8\u10d6\u10e0\u10d3\u10d4\u10d1\u10d0. \u10d3\u10d0\u10d0\u10d5\u10d0\u10d3\u10d4\u10d1\u10d8\u10e1 \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10e3\u10da\u10d8 \u10de\u10e0\u10dd\u10d1\u10da\u10d4\u10db\u10d0 \u10d8\u10e1 \u10d0\u10e0\u10d8\u10e1, \u10e0\u10dd\u10db \u10db\u10d8\u10e1\u10d8 \u10db\u10d8\u10db\u10d3\u10d8\u10dc\u10d0\u10e0\u10d4\u10dd\u10d1\u10d0 \u10ee\u10e8\u10d8\u10e0\u10d0\u10d3 \u10e8\u10d4\u10e3\u10db\u10e9\u10dc\u10d4\u10d5\u10d4\u10da\u10d8\u10d0 \u10db\u10d0\u10dc\u10d0\u10db, \u10e1\u10d0\u10dc\u10d0\u10db \u10eb\u10d5\u10da\u10d8\u10e1 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d0 \u10d0\u10e0 \u10d2\u10d0\u10dc\u10d5\u10d8\u10d7\u10d0\u10e0\u10d3\u10d4\u10d1\u10d0. \u10d2\u10d0\u10dc\u10e1\u10d0\u10d9\u10e3\u10d7\u10e0\u10d4\u10d1\u10d8\u10d7 \u10db\u10dc\u10d8\u10e8\u10d5\u10dc\u10d4\u10da\u10dd\u10d5\u10d0\u10dc\u10d8\u10d0 \u10d1\u10d0\u10e0\u10eb\u10d0\u10e7\u10d8\u10e1, \u10ee\u10d4\u10e0\u10ee\u10d4\u10db\u10da\u10d8\u10e1\u10d0 \u10d3\u10d0 \u10db\u10d0\u10ef\u10d8\u10e1 \u10db\u10dd\u10e2\u10d4\u10ee\u10d8\u10da\u10dd\u10d1\u10d4\u10d1\u10d8, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":72057,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_sheni_byline":"giorgi","footnotes":""},"categories":[272],"tags":[11712,11713],"class_list":["post-88141","post","type-post","status-publish","format-standard","has-post-thumbnail","category-272","tag-11712","tag-11713"],"_links":{"self":[{"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/posts\/88141","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/comments?post=88141"}],"version-history":[{"count":2,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/posts\/88141\/revisions"}],"predecessor-version":[{"id":88144,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/posts\/88141\/revisions\/88144"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/media\/72057"}],"wp:attachment":[{"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/media?parent=88141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/categories?post=88141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sheniekimi.ge\/ambebi\/wp-json\/wp\/v2\/tags?post=88141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}